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process for preparation of vitamin c manufacturers

  • Process for Preparation of Vitamin C and Method for ...

    2019-6-4 · Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acid on calcium carbonate in water. In recent years, the determination of vitamin C has become an important subject in the field of biochemistry and commercial foods. This is because vitamin C plays an important role in maintaining human health.

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  • Process for Preparation of Vitamin C and Method for ...

    The prepartaion method and methods for the determination of vitamin C are spectrophotometric methods and non-spectrophotometric methods (Arya and Mahajan, 1997). For non-spectrophotometric methods are such as high-performance liquid chromatography (HPLC), titration, enzymatic method and fluorometry (Arya, Mahajan and Jain, 2000).

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  • Process for Preparation of Vitamin C and Method for ...

    In recent years, the determination of vitamin C has become an important subject in the field of biochemistry and commercial foods. Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acid on calcium carbonate in water.

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  • Industrial Fermentation of Vitamin C - Industrial ...

    2016-3-28 · Today, a two-step fermentation process is widely used by Chinese manufacturers for vitamin C production due to low cost and high product quality. When compared with the classical process, a mixed fermentation consisting of Ketogulonicigenium vulgare and Bacillus spp. is conducted to convert L-sorbose to the intermediate 2-keto-L-gulonic acid (2-KLG) in the two-step fermentation process.

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  • [PDF] Process for Preparation of Vitamin C and

    Today, vitamin C identical to that occurring in nature is produced on a very large industrial scale. The ultimate raw material for the production of vitamin C (ascorbic acid) is corn or wheat. This is converted via starch to glucose by specialist companies, and then to sorbitol.

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  • What's the Process for Manufacturing Vitamin

    2020-6-11 · Due to the incredibly intricate nature of vitamin manufacturing, many new brand owners prefer partnering with an experienced contract manufacturer who can guide them through every step of the way. The manufacturing process will generally take 12-16 weeks for new orders and 8-12 weeks for existing/re-orders.

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  • Vitamin C manufacturer | Worldwide supplier of vitamins

    Pharmavit is your vitamin C manufacturer into the nutraceutical and pharmaceutical industry. Our Vitamin C is obtained from the highest quality raw material and follows a strict quality and traceability control. This ensures maximum purity and guarantees the end product’s efficacy and safety.

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  • EconPapers: Process for Preparation of Vitamin C and ...

    2019-7-27 · Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets. Surgery & Case Studies: Open Access Journal, 2018, vol. 1, issue 3, 52-65. Abstract: Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acid on calcium carbonate in water.

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  • Vitamin Manufacturer - Overview Of SMP Nutra

    A process for the preparation of L-ascorbic acid by reacting 2-keto-L-gulonic acid with aqueous mineral acid in a solvent mixture containing an inert organic solvent, an aliphatic ketone and also an acid chloride.

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  • Vitamin Manufacturer - Overview Of SMP Nutra

    2016-2-10 · Actually, we are one among the leading vitamin c manufacturers to synthesize vitamin C and now, it has been a leading manufacturer for more than 20 years. Quality Liqiud Vitamins As the leading manufacturer of vitamin products in the world, we know the increasing significance of food element quality, offering the most comprehensive and reliable ...

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  • Vitamin C Manufacturers | Private Label Vitamins

    The addition of 0.5ppm H2O2 did not greatly greater vitamin C losses should be expected as residual SF J Chem Res Volume 2 · Issue 1 · 1000007 ISSN:XXXX-XXXX SFJCR, an open access journal page 12 of 17 Citation: Krishnasarma Pathy (2018) Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets.

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  • (PDF) Process for Preparation of Vitamin C and

    “Liposomal vitamin is packaged like a bodily cell so it passes through the digestive barrier and delivers more than 90% of the nutrient directly to the bloodstream within Minutes. With over 90% of your cells will be bathed in Liposomal vitamin C.” – Dr. Alec Banham, at the Babraham Institute in Cambridge, UK.

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  • LipoCellTech™ – The future of vitamins

    2000-4-3 · PROCESS FOR THE PREPARATION OF VITAMIN A, INTERMEDIATES, AND PROCESS FOR THE PREPARATION OF THE INTERMEDIATES (PAT - EP1085008) TAKAHASHI TOSHIYA, FURUTANI ATSUSHI, SEKO SHINZO. SUMITOMO CHEMICAL COMPANY, LIMITED. Patent: Publ. of Application with search report - European Patent ...

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  • How vitamin is made - ingredients of, making, history ...

    2014-1-1 · Benczedi et al. (2011) US Patent 8,017,060—Process for the preparation of extruded delivery systems (“particularly useful for the controlled release of flavoring or perfuming ingredients”) Bio-Dar (LycoRed) 2 • Blatt et al. (2006) US Patent 7,097,868—Stable coated microcapsules. National Starch: 16 •

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  • PROCESS FOR THE PREPARATION OF VITAMIN A,

    2016-3-22 · The structure of vitamin A was first elucidated by the Nobel Prizewinner, Paul Karrer in 1929e31 afterextraction fromthe liver oils of halibut and mackerel.2,3 It is a C 20 diterpenoid containing four isoprene units (Fig. 1). It was isolated and crystallised by Holmes and Corbet from fish liver oils in 1937.4,5 It is important to

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  • Microencapsulation of Vitamins, Minerals, and ...

    The invention claimed is: 1. A process for the preparation of a compound of formula (I) comprising a step in which (i) a compound of formula (II) is reacted with a compound of formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a palladium ...

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  • Development of the industrial synthesis of vitamin A

    I claim 1. A process for the preparation of crystalline vitamin D 3 from a vitamin D 3 resin which process comprises dissolving a vitamin D 3 resin in methyl formate and cooling the resultant solution. 2. The process of claim 1 wherein the resultant solution is cooled to a temperature of from about -20°C to about 15°C.

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  • (PDF) Process for Preparation of Vitamin C and

    The addition of 0.5ppm H2O2 did not greatly greater vitamin C losses should be expected as residual SF J Chem Res Volume 2 · Issue 1 · 1000007 ISSN:XXXX-XXXX SFJCR, an open access journal page 12 of 17 Citation: Krishnasarma Pathy (2018) Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets.

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  • Scilit | Article - Process for Preparation of Vitamin C ...

    2018-6-15 · Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets Krishnasarma Pathy

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  • Preparation of vitamin C liposomes by rapid

    2019-6-1 · Vitamin C (VC) liposomes were prepared by the rapid expansion of supercritical solution process (RESS) in this study. The combined effects of temperature, pressure, and feeding ratio of VC against phosphatidylcholine (PC) on the drug loading content of the prepared liposomes were determined and discussed using response surface analysis.

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  • Vitamin C analysis - University of California, Los Angeles

    2016-5-5 · Vitamin C Sample Preparation: Using an analytical balance, weigh a vitamin C “tablet” and place it in a mortar. Grind with a pestle into fine powder. Weigh approximately 0.10 g of the powder to a tenth of a milligram and transfer it quantitatively into a 125-mL Erlenmeyer flask. Record the weight in …

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  • In dustria l Pro duction of l-Ascorbic Aci d (Vitamin C ...

    2013-11-21 · Abstract. l-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor.Industrially produced l-ascorbic acid is widely used in the feed, food, and pharmaceutical sector as nutritional supplement and preservative, making use of its antioxidative properties.Until recently, the Reichstein–Grüssner process, designed in 1933, was the ...

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  • China Has Near Monopoly On World Vitamin C

    2021-7-12 · Vitamin C, also known as ascorbic acid, is a critical food preservative and a favorite vitamin all over the world. But now 80 percent of it is made in one place in the world — a place that has ...

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  • Scilit | Article - Process for Preparation of Vitamin C ...

    2018-6-15 · Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets Krishnasarma Pathy

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  • Vitamin C Injection Products list Products Ceva ...

    Vitamin C enhances tissue growth and wound healing, acts as a major antioxidant to neutralise free radicals, improves immune function and response, especially in stressed horses, acts to reduce stress, and is critical in the maintenance and repair of joint cartilage and tendons. As a water soluble vitamin, Ascorbic acid must be supplemented ...

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  • Vitamin C analysis - University of California, Los Angeles

    2016-5-5 · Vitamin C Sample Preparation: Using an analytical balance, weigh a vitamin C “tablet” and place it in a mortar. Grind with a pestle into fine powder. Weigh approximately 0.10 g of the powder to a tenth of a milligram and transfer it quantitatively into a 125-mL Erlenmeyer flask. Record the weight in …

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  • Gummy Vitamin Manufacturing - SMPNutra.com |

    2018-8-28 · An estimated 95% of the world’s vitamin C is produced in China currently. China had exported US879.6 million worth of vitamin C last year, a 114.3% growth as compared to year 2016, figures from China Chamber of Commerce for Import & Export of Medicines & Health Products (CCCMHPIE) have shown. Vitamin C – China’s most exported vitamin .

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  • 'China-free' vitamin C: Industry defends standards

    The main objective of this study was to evaluate vitamin c loss following vegetable manipulation stages, reception, storage, preparation, and distribution, in commercial and institutional restaurants. Seven vegetables were used: lettuce, carrots, chicory, collard greens, cauliflower, cabbage and tom …

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  • [Vitamin C loss in vegetables during storage,

    2013-11-21 · Abstract. l-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor.Industrially produced l-ascorbic acid is widely used in the feed, food, and pharmaceutical sector as nutritional supplement and preservative, making use of its antioxidative properties.Until recently, the Reichstein–Grüssner process, designed in 1933, was the ...

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  • In dustria l Pro duction of l-Ascorbic Aci d (Vitamin C ...

    2016-11-22 · amounts of calcium. Tomatoes contain a lot of vitamin A, vitamin C and vitamin B3. They have small amounts of other B vitamins, and vitamin E. Tomato-based processed food consumption in India is growing at an annual rate of over 30% creating massive demand for existing processors like Hindustan Unilever and Nestle,

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  • Tomato Processing and Tomato based Products, Value

    During the processing of macaroni, oven drying for 9 to 12 hours at 50°C resulted in a 14% loss of vitamin A. However, the same treatment caused the loss of only approximately 5% of b-carotene. Furthermore, drying for 3 to 5 hours at 95°C caused the destruction of 23% of vitamin A but only 8% of b-carotene.

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  • Vitamin C preparation and process for its preparation ...

    The vitamin C preparation consisting of ascorbic acid microparticles, which are formed as bubbles or hollow spheres and have an outer diameter smaller than 0.1 mm. Thereby, the ratio of solid mass to the solid surface is opposite that abruptly reduced in crystalline ascorbic acid and increases the relative particle surface. The effect is a relatively high rate of dissolution of the ...

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  • Food Preparation, Processing, and Vitamin C ...

    2018-12-9 · Vitamin C (VC), a micronutrient known for its anti-oxidant and immune-enhancing properties, can be found in many fruits and vegetables (Leong & Oey, 2012). However, food preparation and processing can compromise the levels ascorbate and its function before reaching the consumer.

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  • Industrial production of L-ascorbic Acid (vitamin C)

    L-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor. Industrially produced L-ascorbic acid is widely used in the feed, food, and pharmaceutical sector as nutritional supplement and preservative, making use of …

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  • Quali C: Vitamin C | DSM Human Nutrition & Health

    Vitamin C is a water-soluble nutrient that has important functions in the body, such as normal function of the immune system, and anti-oxidant capabilities, as well as aiding everything from iron absorption to normal formation of collagen for the normal function of blood vessels, bones, teeth, skin, heart and gums.

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  • Determination of Vitamin C Concentration by Titration

    2021-5-9 · Sample Preparation For vitamin C tablets: Dissolve a single tablet in 200 mL of distilled water (in a volumetric flask if possible). For fresh fruit juice: Strain the juice through cheesecloth to remove seeds and pulp which may block pipettes. For packaged fruit juice: This may also need to be strained through cheesecloth if it contains a lot ...

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  • [Vitamin C loss in vegetables during storage,

    The main objective of this study was to evaluate vitamin c loss following vegetable manipulation stages, reception, storage, preparation, and distribution, in commercial and institutional restaurants. Seven vegetables were used: lettuce, carrots, chicory, collard greens, cauliflower, cabbage and tom …

    Get Price
  • Vitamin C - Health Professional Fact Sheet

    2021-7-17 · Oral vitamin C produces tissue and plasma concentrations that the body tightly controls. Approximately 70%–90% of vitamin C is absorbed at moderate intakes of 30–180 mg/day. However, at doses above 1 g/day, absorption falls to less than 50% and absorbed, unmetabolized ascorbic acid is excreted in the urine [ 4 ].

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  • Innopharma producer & manufacturer of vitamins &

    Ascorbic acid (vitamin C) is easily destroyed during processing and storage through the action of metals such as copper and iron. Both exposure to oxygen and prolonged heating in the presence of oxygen destroy ascorbic acid; thus, the stability of vitamin C in fortified foods depends on the product, processing method, and type of packaging used.

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  • stability - DSM

    2007-6-2 · Firms such as Weisheng, which had planned to produce 3,000 tons of vitamin C a year, stepped up its capacity to 30,000 tons a year by mid-2004, which it claims is the largest in the world.

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  • Food Preparation, Processing, and Vitamin C ...

    2018-12-9 · Vitamin C (VC), a micronutrient known for its anti-oxidant and immune-enhancing properties, can be found in many fruits and vegetables (Leong & Oey, 2012). However, food preparation and processing can compromise the levels ascorbate and its function before reaching the consumer.

    Get Price
  • Ascorbic Acid, Vitamin C Manufacturers, SDS

    2021-1-23 · Ascorbic Acid, Vitamin C Reagent Grade Manufacturers, with SDS GHS MSDS Sheet, also Micro Encapsulated Ascorbic acid: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India.

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  • How to Make Your Own Liposomal Vitamin C

    2018-11-20 · Update 2014-2015: Another fellow researcher by the name of Chris provided us with a new and novel way to make the highest quality liposomal vitamin C. You can visit his website by clicking HERE. Vitamin C is the most used supplement in the world. There is good reason for this as the science behind the many benefits of vitamin C is solid.

    Get Price
  • Innopharma producer & manufacturer of vitamins &

    Ascorbic acid (vitamin C) is easily destroyed during processing and storage through the action of metals such as copper and iron. Both exposure to oxygen and prolonged heating in the presence of oxygen destroy ascorbic acid; thus, the stability of vitamin C in fortified foods depends on the product, processing method, and type of packaging used.

    Get Price
  • stability - DSM

    2021-7-15 · What Differentiates Us from Other Vitamin Manufacturers? Our team of knowledgeable Production Specialists have successfully created over 1,600 vitamin and supplement products for nutraceutical brands of all sizes. They will work with you throughout the vitamin manufacturing process to create a custom product from scratch or update your existing formula to maximize your sales.

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  • Award-Winning Vitamin Manufacturers in USA -

    2017-12-6 · Top Vitamin Manufacturers BASF SE. BASF SE is a German chemical company that has a diversified portfolio, divided into five major segments, including chemicals, performance products, agricultural solutions, oil and gas, and functional materials and solutions.Their product for human nutrition includes dietary supplements, functional nutrition, medical nutrition, infant & maternal nutrition ...

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  • Top 5 Vitamin Manufacturers Across the Globe |

    1997-9-19 · For example, if an intended ingredient is vitamin C, then an effective amount of vitamin C would include an amount of vitamin C sufficient to provide 10% or more of the RDA. Typically, where the tablet includes a mineral or vitamin, it will incorporate higher amounts, preferably about 100% or more of the applicable RDA.

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  • Effervescent granules and methods for their

    2021-7-17 · Chemistry: . Vitamin B 12 (cyanocobalamin) is a water soluble vitamin with complex structure. The empirical formula of cyanocobalamin is C 63 H 90 N 14 O 14 PCO. The structure of vitamin B 12 consists of a corrin ring with a central cobalt atom. The corrin ring is almost similar to the tetrapyrrole ring structure found in other porphyrin compounds e.g. heme (with Fe) and chlorophyll (with Mg).

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  • Innopharma producer & manufacturer of vitamins &

    2021-5-9 · Sample Preparation For vitamin C tablets: Dissolve a single tablet in 200 mL of distilled water (in a volumetric flask if possible). For fresh fruit juice: Strain the juice through cheesecloth to remove seeds and pulp which may block pipettes. For packaged fruit juice: This may also need to be

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  • Determination of Vitamin C Concentration by Titration

    2019-7-3 · guide to good manufacturing practice for manufacturers of food supplements 2.4 Quality Assurance The fundamental aim of Quality Assurance is reproducibility, so that the product sold to …

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  • Good Manufacturing Practice for Manufacturers of Food ...

    2008-3-11 · Nobel Peace Prize, has argued in his book, Vitamin-C and the Common Cold, that humans should be consuming around 500 mg of vitamin-C a day (considered by many doctors to be an excessive amount) to help ward off the common cold and prevent cancer. Vitamin-C is a six carbon chain, closely related chemically to glucose.

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  • CHL 212 – Quantitative Analysis

    2016-10-6 · vitamin C loss Heating legumes destroys substances which inhibit the uptake of proteins into the body. Destroys some toxins in certain legumes. Heating flour increases niacin available to the body. Cooking egg whites and fish makes biotin and vitamin B1 available. Grilling lowers fat content of food Frying can increase fat content

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  • Lesson 3 KITCHEN AND FOOD MANAGEMENT EFFECTS

    14 小时前 · Download Ebook Vitamin C Solution Vitamin C 'Provides an up-to-the-minute, comprehensive analysis of the most recent theoretical and clinical developments in vitamin C research--integrating a wide variety of interdisciplinary studies into a single-source volume. Highlights the redox properties of vitamin C, including regeneration, participation ...

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  • What Does Cooking Do to Vitamin C? | Livestrong.com

    Vitamin C supplements made from whole food sources, like Truth Nutrition Organic Vitamin C, keep ascorbic acid paired with bioflavonoids and other plant compounds as nature intended. This full-spectrum composite of vitamin C slows the digestion and release of ascorbic acid into the bloodstream, improving its absorption and utilization in the body.

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  • Riboflavin–vitamin b2 fermentation process

    1 天前 · Sample Preparation For vitamin C tablets: Dissolve a single tablet in 200 mL of distilled water (in a volumetric flask if possible). For fresh fruit juice: Strain the juice through cheesecloth to remove seeds and pulp which may block pipettes. Determination of Vitamin C Concentration by Titration

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  • How to Make Your Own Liposomal Vitamin C

    2018-11-20 · Update 2014-2015: Another fellow researcher by the name of Chris provided us with a new and novel way to make the highest quality liposomal vitamin C. You can visit his website by clicking HERE. Vitamin C is the most used supplement in the world. There is good reason for this as the science behind the many benefits of vitamin C is solid.

    Get Price
  • Ascorbic Acid, Vitamin C Manufacturers, SDS

    2021-1-23 · Ascorbic Acid, Vitamin C Reagent Grade Manufacturers, with SDS GHS MSDS Sheet, also Micro Encapsulated Ascorbic acid: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India.

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  • Fermentation Process of Vitamins - Labmonk

    2021-2-17 · 4.1.5 Vitamin C. Vitamin C or ascorbic acid is an odourless, white, crystalline compound which is stable in its dry form. Due to its high water solubility, losses due to leaching can be a problem in some processing procedures. Ascorbic acid is readily oxidised.

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  • ANNEX 4 - MICRONUTRIENT FORTIFICATION OF

    2018-2-26 · The researchers found that it isn’t just water and heat, but time as well that plays a critical role in the Vitamin C content of these vegetables. Peppers began with 15.39 mg/25 ml Vitamin C in its raw form and saw its content drastically decline to 13.58 after cooking for 5 minutes, 9.96 after 15 minutes, and 5.43 after 30 minutes.

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  • 10: Vitamin C Analysis (Experiment) - Chemistry

    2016-1-26 · Vitamin D is functionally a hormone, rather than a vitamin, and is one of the most important biological regulators of calcium metabolism,in conjunction with parathyroid hormone and calcitonin. As calciferol enters the circulation, it is metabolized to several forms, the primary one being 25-hydroxycalciferol (25-OH-D) (1). The first step in the

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  • Does Heat Destroy Vitamin C? - LivOn Labs

    1997-9-19 · For example, if an intended ingredient is vitamin C, then an effective amount of vitamin C would include an amount of vitamin C sufficient to provide 10% or more of the RDA. Typically, where the tablet includes a mineral or vitamin, it will incorporate higher amounts, preferably about 100% or more of the applicable RDA.

    Get Price
  • Ascorbic Acid, Vitamin C Manufacturers, SDS

    2021-1-23 · Ascorbic Acid, Vitamin C Reagent Grade Manufacturers, with SDS GHS MSDS Sheet, also Micro Encapsulated Ascorbic acid: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India.

    Get Price
  • How to Make Your Own Liposomal Vitamin C

    2018-11-20 · Update 2014-2015: Another fellow researcher by the name of Chris provided us with a new and novel way to make the highest quality liposomal vitamin C. You can visit his website by clicking HERE. Vitamin C is the most used supplement in the world. There is good reason for this as the science behind the many benefits of vitamin C is solid.

    Get Price
  • BASF to close down vitamin C production -

    2005-12-15 · World number two vitamin maker BASF said today it will shut down. its vitamin C plant in Denmark by the year-end, bringing to a halt. all of its production of the vitamin. Rumours about the future of the small plant at Grenaa gained credibility in August when BASF reported a €26 million charge for restructuring of its vitamin C operations.

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  • 10: Vitamin C Analysis (Experiment) - Chemistry

    Water-soluble vitamins (B-group and C) are more unstable than fat-soluble vitamins (K, A, D and E) during food processing and storage. The most unstable vitamins include: folate. thiamine. vitamin C. More stable vitamins include: niacin (vitamin B3) vitamin K. vitamin D.

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  • Food processing and nutrition - Better Health Channel

    1997-9-19 · For example, if an intended ingredient is vitamin C, then an effective amount of vitamin C would include an amount of vitamin C sufficient to provide 10% or more of the RDA. Typically, where the tablet includes a mineral or vitamin, it will incorporate higher amounts, preferably about 100% or more of the applicable RDA.

    Get Price
  • Effervescent granules and methods for their

    2009-8-6 · 2. Preparation of the vaccine strain (called vaccine virus): The virus must first be adapted for use in manufacturing vaccine.To make the vaccine virus less dangerous and better able to grow in hen’s eggs (the production method used by most manufacturers), the virus is mixed with a standard laboratory virus strain and the two are allowed to grow together.

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  • Pandemic influenza vaccine manufacturing process

    2021-1-22 · Valor process engineering solutions also enables you to preserve manufacturing know-how, including manufacturing best practices, libraries, and customer data preparation flows. BOM Connector Electronic Manufacturing Services (EMS) companies need to provide quotations for many more projects than those that make it into production.

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  • Valor Process Engineering Solutions | Siemens Digital ...

    2015-9-10 · b Not separated into types of glass produced, since batch preparation is the same for all types. Particulate emissions are negligible because almost all plants utilize some form of control (i. e., baghouses, scrubbers, centrifugal collectors). c Control efficiencies for the various devices are applied only to the average emission factor.

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  • 11.15 Glass Manufacturing - US EPA

    2015-9-7 · J.Med.Chem. 2002, 45, 1757-1766 describes a process for preparation of compound of formula (III) as depicted in scheme -II. SCHEME - II The process for preparation of mesylate salt of dabigatran etexilate and its polymorphic forms was disclosed in US2005/234104.

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