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pharmacokinetics of tilmicosin after oral using method

  • Pharmacokinetics of tilmicosin after oral

    Objective: To determine the pharmacokinetics of tilmicosin after oral administration of a single dose of tilmicosin base in swine. Animals: 10 healthy swine. Procedure: Tilmicosin base was administered via stomach tube at a single dose of 20 mg/kg (n = 5) or 40 mg/kg (5). Blood samples were obtained from a jugular vein immediately before and at 10, 20, and 30 minutes and 1, 2, 3, 4, 6, 8, 12, 24, 36, 48, 72, 96, and 120 hours after administration of tilmicosin.

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  • Pharmacokinetics of tilmicosin after oral

    2019-10-24 · Objective—To determine the pharmacokinetics of tilmicosin after oral administration of a single dose of tilmicosin base in swine. Animals—10 healthy swine. Procedure—Tilmicosin base was administered via stomach tube at a single dose of 20 mg/kg (n = 5) or 40 mg/kg (5). Blood samples were obtained from a jugular vein immediately before and at 10, 20, and 30 minutes and 1, 2, 3, 4, 6, 8, 12, …

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  • Pharmacokinetics of Tilmicosin in broiler chickens

    Pharmacokinetic parameters of tilmicosin after administration of Biomicosin 25% oral solution were: maximum plasma concentration (Cmax) 0.583 0.03 g/mL, time to reach maximum plasma concentrations (Tmax) 3.0 0.0 h, area under the concentration-time curve (АUC0 LOQ) 15.95 1.24 g.h/mL, elimination half-life (t1/2 ) 32.36 0.93 h and mean residence time (MRT) 44.74 1.15 h.

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    2007-1-15 · Shen, J., Li, C., Jiang, H., Zhang, S., Guo, P., Ding, S. and Li, X., 2005. Pharmacokinetics of tilmicosin after oral administration in swine. American Journal of Veterinary Research, 66, 1071–1074. PubMed Article CAS Google Scholar Scorneaux, B. and Shryock, T.R., 1998a.

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  • Pharmacokinetics of tilmicosin (Provitil powder and ...

    A bioavailability and pharmacokinetics study of powder and liquid tilmicosin formulations was carried out in 18 healthy chickens according to a single-dose, two-period, two-sequence, crossover randomized design. The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each …

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    In conclusion, tilmicosin was rapidly absorbed and slowly eliminated after oral administration of single dose of tilmicosin aqueous and powder formulations. Provitil and Pulmotil AC can be used as interchangeable therapeutic agents.

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  • Pharmacokinetics and tissue depletion of tilmicosin in

    2020-7-29 · -1 after being on treatment for 3 and 4 days, respectively. With oral dosing at 200 ppm for 5 days, the highest concentrations of tilmicosin were reached in liver, followed by kidney, lung, and muscle tissues. Tissue samples were analyzed until all samples from two subsequent time periods were below the limit of detection of the assay.

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  • Pharmacokinetics of tilmicosin in healthy pigs and in pigs ...

    A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal

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  • Pharmacokinetics of tilmicosin (Provitil powder and

    2017-4-11 · Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid) oral formulations in chickens.pdf,Veterinary Research Communications, 31 (2007) 477–485 DOI: 10.1007/s11259-006-3543-6 C? Springer 2007 Pharmacokinetics of Tilmicosin (Provitil Powder and Pulmotil Liquid AC) Oral Formulations in Chickens E.A. Abu-Basha1,?, N.M. Idkaidek2 and A.F. Al-

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  • Determination of antibacterial agent tilmicosin in

    The recoveries ranged from 95 to 99% for the three tested concentrations. The LC-MS/MS method described herein was simple, fast and less laborious than other methods, achieved high sensitivity using a small sample volume, and was successfully applied to pharmacokinetic studies of tilmicosin enteric granules after oral delivery to pigs.

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  • Pharmacokinetics of tilmicosin after oral

    2019-10-24 · Objective—To determine the pharmacokinetics of tilmicosin after oral administration of a single dose of tilmicosin base in swine. Animals—10 healthy swine. Procedure—Tilmicosin base was administered via stomach tube at a single dose of 20 mg/kg (n = 5) or 40 mg/kg (5). Blood samples were obtained from a jugular vein immediately before and ...

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  • Pharmacokinetics of tilmicosin (Provitil powder and ...

    The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each chicken after an overnight fast on two treatment days separated by a 2-week washout period. A modified rapid and sensitive HPLC method was used for determination of tilmicosin concentrations in chicken plasma.

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    A bioavailability and pharmacokinetics study of powder and liquid tilmicosin formulations was carried out in 18 healthy chickens according to a single-dose, two-period, two-sequence, crossover randomized design. The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each chicken after an overnight fast on two treatment days separated by a 2-week washout period.

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  • Pharmacokinetics and tissue depletion of tilmicosin in

    2020-7-29 · -1 after being on treatment for 3 and 4 days, respectively. With oral dosing at 200 ppm for 5 days, the highest concentrations of tilmicosin were reached in liver, followed by kidney, lung, and muscle tissues. Tissue samples were analyzed until all samples from two subsequent time periods were below the limit of detection of the assay.

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  • Pharmacokinetics of tilmicosin in healthy pigs and in pigs ...

    Tilmicosin in pigs 433 www.vetsci.org Fig. 1. Histopathological image of pig l ung at 48 h after intranasal inoculation with Haemophilus parasuis (left) or sterilized saline (right). H&E stain. 400×. by oral gavage in a single 40 mg/kg dose. This dose was based on the clinical outcome from a 400 mg/kg feed (about 40 mg/kg body weight ...

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  • Tilmicosin enteric granules and premix to pigs ...

    The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    2007-1-15 · A bioavailability and pharmacokinetics study of powder and liquid tilmicosin formulations was carried out in 18 healthy chickens according to a single-dose, two-period, two-sequence, crossover randomized design. The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each chicken after an overnight fast on two treatment days separated by a 2-week washout period.

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  • Pharmacokinetics and bioavailability of solid

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

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  • Tilmicosin enteric granules and premix to pigs ...

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

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  • Pharmacokinetics of tilmicosin after oral

    2005-6-1 · Abstract. OBJECTIVE:To determine the pharmacokinetics of tilmicosin after oral administration of a single dose of tilmicosin base in swine. ANIMALS:10 healthy swine. PROCEDURE:Tilmicosin base was administered via stomach tube at a single dose of 20 mg/kg (n = 5) or 40 mg/kg (5). Blood samples were obtained from a jugular vein immediately before ...

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    2007-1-15 · A bioavailability and pharmacokinetics study of powder and liquid tilmicosin formulations was carried out in 18 healthy chickens according to a single-dose, two-period, two-sequence, crossover randomized design. The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each chicken after an overnight fast on two treatment days separated by a 2-week washout period. A ...

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  • Pharmacokinetics of tilmicosin in healthy pigs and

    A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations.

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  • Pharmacokinetics and pharmacodynamics of

    prepared using biodegradable materials such as lipids (5). These nanoparticles, which should be stable and nontoxic, can improve the efficacy and safety of loaded drugs (8). Abstract: Tilmicosin (TLM) is a semisynthetic antimicrobial agent used mainly in poultry and cattle, but it has relatively poor oral …

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  • Pharmacokinetics and bioavailability of three promising ...

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

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  • Tilmicosin enteric granules and premix to pigs ...

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

    Get Price
  • Tilmicosin enteric granules and premix to pigs ...

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin.

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  • Tilmicosin enteric granules and premix to pigs ...

    The recoveries ranged from 95 to 99% for the three tested concentrations. The LC-MS/MS method described herein was simple, fast and less laborious than other methods, achieved high sensitivity using a small sample volume, and was successfully applied to pharmacokinetic studies of tilmicosin enteric granules after oral delivery to pigs.

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  • Determination of antibacterial agent tilmicosin in

    2020-10-1 · The drug concentrations in plasma and ileum content vs time curves after oral administration of tilmicosin premix were illustrated in Fig. 1, Fig. 2.After oral dosing, the tilmicosin concentration in plasma and ileum content were best fitted with noncompartmental model ().The drug concentration in plasma was lower than intracellular MIC (2 μg/mL) during 0–48 h.

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  • Pharmacokinetics of tilmicosin after oral application of ...

    The purpose of the present study was to determine the main pharmacokinetic parameters of tilmicosin after oral application of Pulmotil G 200-premix (Elanco). Eight clinically healthy Danube White pigs 4 from both genders, at the age of 9-10 weeks, weighing from 9 to 14.55 kg were used. Pulmotil G 200-premix was applied once at a dose of 16 mg/kg body weight tilmicosin.

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  • Pharmacokinetics of tilmicosin in equine tissues and ...

    2008-2-1 · Tilmicosin was not detected in equine plasma or tissues after oral administration at this dose. With s.c. injection, tilmicosin concentrations reached a maximum concentration of approximately 200 ng/mL in the plasma of the horses. Tilmicosin concentrations in plasma persisted with a mean residence time (MRT) of 19 h.

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  • Comparison of pharmacokinetics of tilmicosin in

    2019-6-17 · Each pig received a single oral dose of 20 mg/kg bodyweight of tilmicosin, given 3–4 hours after inoculation in infected pigs. Blood samples were collected before drug administration and up to 48 hours after tilmicosin administration. Concentrations of tilmicosin in …

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  • Pharmacokinetic and pharmacodynamic properties of ...

    2021-4-16 · tilmicosin pharmacokinetics between the two species. ... A safety study was performed using high oral or intravenous doses, and ... and lung tissue samples using this method was 11 minutes. Examples of chromatograms of a tilmicosin-free sheep serum sample, and a sheep

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  • Frontiers | Pharmacokinetic and Pharmacodynamic ...

    2019-6-12 · The MIC values of tilmicosin with inoculums of 10 5 and 10 7 CFU/ml were 0.01 and 0.02 μg/ml, respectively, using the microdilution method. For inoculums of 10 5, 10 7, and 10 9 CFU, the MIC values were 0.02, 0.04, and 0.16 μg/ml using the agar dilution method, respectively. Time-Killing Curve Fitting and Analysis

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  • Pharmacokinetics and Tissue Residues of Tylosin in

    2016-1-18 · The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with Vd(area) of 6 L/kg ...

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  • Tilmicosin- and florfenicol-loaded hydrogenated

    The pharmacokinetics (PKs) of TIL- and FF-loaded hydrogenated castor oil (HCO)-solid lipid nanoparticles (SLN) were performed in healthy pigs. The results indicated that TIL and FF showed synergistic or additive antibacterial activities against APP, S. suis and HPS with the fractional inhibitory concentration (FIC) ranging from 0.375 to 0.75.

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  • Solid Lipid Nanoparticles for Duodenum Targeted

    After the enteric coating of the granules containing SLNs and P-gp inhibitor of polysorbate-80, the oral absorption of tilmicosin was improved 2.72 fold, and the T max was shortened by 2 h. The combination of duodenum-targeted release and P-gp inhibitors was an effective method to improve the oral absorption of tilmicosin.

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  • Pharmacokinetics of sarizotan after oral

    Pharmacokinetics of sarizotan after oral administration of single and repeat doses in healthy subjects. Krösser S(1), Tillner J, Fluck M, Ungethüm W, Wolna P, Kovar A. Author information: (1)Department of Clinical Pharmacology and Pharmacokinetics, Merck KGaA, Darmstadt, Germany.

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  • Comparative pharmacokinetics of active alkaloids

    Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method. Chen Y(1), Li Y, Wang Y, Yang Q, Dong Y, Weng X, Zhu X, Wang Y, Gong Z, Zhang R.

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  • Preparation, characterization, and pharmacokinetics of ...

    2020-12-1 · Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and effects in vitro/in vivo.Eudragit® E PO was selected as the carrier, and TMS dissolution in ...

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  • Comparison of pharmacokinetics of tilmicosin in

    2019-6-17 · Each pig received a single oral dose of 20 mg/kg bodyweight of tilmicosin, given 3–4 hours after inoculation in infected pigs. Blood samples were collected before drug administration and up to 48 hours after tilmicosin administration. Concentrations of tilmicosin in …

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  • Pharmacokinetics and Efficacy of Tilmicosin in the ...

    2014-6-5 · two days, and if negative, daily until 14 days after inoculation. The bacteria were identified by the techniques described by Carter (1984) [14]. 2.11. Analytical Methods The free tilmicosin concentrations in serum and bronchial secretions were measured by a microbiological assay technique [15] using Microccouslutea (ATCC 9431) as test organism ...

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  • Pharmacokinetic and pharmacodynamic properties of ...

    2021-4-16 · tilmicosin pharmacokinetics between the two species. ... A safety study was performed using high oral or intravenous doses, and ... and lung tissue samples using this method was 11 minutes. Examples of chromatograms of a tilmicosin-free sheep serum sample, and a sheep

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  • Milk and Blood Pharmacokinetics of Tylosin and

    2014-8-6 · In conclusion, it may be stated that milk concentration of tylosin after parenteral administration is higher than expected like tilmicosin and needs more withdrawal period for milk than reported.

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  • Tilmicosin - an overview | ScienceDirect Topics

    The pharmacokinetics of clarithromycin have been investigated in foals and a dose of 7.5 mg/kg orally q12h is suggested for the treatment of R. equi pneumonia. 35 Azithromycin has been evaluated in foals in two independent pharmacokinetic studies. 34, 114 Azithromycin has a half-life of 11 and 16 hours in foals after oral and IV dosing ...

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  • Pharmacokinetics and Pulmonary Disposition of ...

    2020-7-9 · pharmacokinetics after oral administration with or without fasting in crossbred beagles. Journal of Small Animal Practice, 37, 535-539. Watts, J.L., Yancey, R.J., Jr., Salmon, S.A. & Case, C.A. (1994) A 4-Year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America.

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  • Pharmacokinetics of Isofraxidin in Rat Plasma after

    2007-9-1 · High-performance liquid chromatography coupled with solid phase extraction method was developed for determination of isofraxidin in rat plasma after oral administration of Acanthopanax senticosus extract (ASE), and pharmacokinetic parameters of isofraxidin either in ASE or pure compound were measured. The HPLC analysis was performed on a Dikma Diamonsil RP 18 column (4.6 …

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  • Comparative Pharmacokinetics of Enrofloxacin After ...

    The method of McKellar et al. (1999) was used for analysis of ENR levels in plasma. HPLC separation was carried out by using a mobile phase containing 14% acetonitrile, 85% water, 0.4% triethylamine, and 0.6% phosphoric acid. The mobile phase was filtered by using a 0.45 μm membrane filter.

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  • Determine ka from Oral Data - Method of Residuals

    Determining ka using the Method of Residuals Oral Dosing - Linear One Compartment A 25 mg oral dose of a drug was administered to a healthy volunteer. Blood samples were collected and plasma was separated from each blood sample and analyzed for drug concentration. The collected data are shown in …

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  • Preparation, characterization, and pharmacokinetics of ...

    2020-12-1 · Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and effects in vitro/in vivo.Eudragit® E PO was selected as the carrier, and TMS dissolution in ...

    Get Price
  • Tilmicosin - Food and Agriculture Organization

    2010-5-11 · and an apparent volume of distribution at steady state of 10.4 ± 2.1 L/kg. Oral bioavailability of clarithromycin was 57.3 ± 12.0 %. In a separate study, a single dose of a fatty acid salt formulation of tilmicosin (10 mg/kg) was administered by the intramuscular route to 7 healthy 5- to 8-week-old foals. Concentrations of tilmicosin in

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  • PHARMACOKINETICS AND PULMONARY DISPOSITION

    2008-2-1 · The macrolide antibiotic tilmicosin has potential for treating bacterial respiratory tract infections in horses. A pharmacokinetic study evaluated the disposition of tilmicosin in the horse after oral (4 mg/kg) or subcutaneous (s.c.) (10 mg/kg) administration. Tilmicosin was not detected in equine plasma or tissues after oral administration at this dose. With s.c. injection, tilmicosin ...

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  • Pharmacokinetics of tilmicosin in equine tissues and ...

    2017-8-24 · ethics committee. After 7 days of acclimatization, the animals were randomly divided into five groups of four rabbits each, and tilmicosin (Pulmotil ®) was administered by oral bolus at 12.5 mg/kg b.w. once a day in the early morning for 2 days (group 1), 5 days (group 2), and 7 days (groups 3, 4, and 5).

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  • Kinetics and intrapulmonary disposition of tilmicosin ...

    2014-8-6 · In conclusion, it may be stated that milk concentration of tylosin after parenteral administration is higher than expected like tilmicosin and needs more withdrawal period for milk than reported.

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  • Milk and Blood Pharmacokinetics of Tylosin and

    Tilmicosin (TIM, Pulmotil®) was administered to eight rabbits by oral gavage at a dose of 12.5 mg/kg body weight for 2, 5, and 7 days, and its plasma kinetics and intrapulmonary disposition were investigated. TIM concentrations in plasma samples collected after days 1 and 6 of treatment were measured by high-performance liquid chromatography with ultraviolet detection.

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  • Kinetics and intrapulmonary disposition of tilmicosin ...

    2011-12-26 · Pharmacokinetics of tilmicosin after oral administration in swine. 2005. AM J Vet Res. 66 (6), 1071-1074 82. Sun Yingjian, Diao Xiaoping, Zhang Qidi, Shen Jianzhong*.

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  • Basic pharmacokinetics - Pharmaceutical Press

    2006-4-6 · 6 Basic pharmacokinetics Cp (a) Time log Cp (b) Time Figure 1.2(a) Plasma concentration (C p) versus time profile of a drug showing a one-compartment model. (b) Time profile of a one-compartment model showing log C p versus time. Drug in k 12 k 21 k Central Peripheral Figure 1.3Two-compartment model. k 12, k 21 and k are first-order rate constants: k

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  • Determine ka from Oral Data - Method of Residuals

    Determining ka using the Method of Residuals Oral Dosing - Linear One Compartment A 25 mg oral dose of a drug was administered to a healthy volunteer. Blood samples were collected and plasma was separated from each blood sample and analyzed for drug concentration. The collected data are shown in …

    Get Price
  • Preparation, characterization, and pharmacokinetics of ...

    2020-12-1 · Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and effects in vitro/in vivo.Eudragit® E PO was selected as the carrier, and TMS dissolution in ...

    Get Price
  • TILMICOSIN Shixin Xu, Beijing, China Dieter Arnold, Berlin ...

    2015-10-22 · A published study (Modric, et al. 1998) compared the pharmacokinetics of tilmicosin in cattle and sheep after subcutaneous administration of a dose of 10 mg/kg bw. The pharmacokinetic parameters derived from the time concentration curve (Tmax, Cmax, T1/2, AUC) were not significantly different between species.

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  • Kinetics and intrapulmonary disposition of tilmicosin ...

    Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits. Veterinary Research Communications, 2010. Lorena Lucatello. Download PDF. Download Full PDF Package. This paper. A short summary of this paper.

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  • Therapeutic efficacy of tilmicosin in ovine mammary ...

    2003-1-1 · The concentrations of tilmicosin were determined in 20 milk samples (selected at random in both groups) by the agar plate diffusion method, using 7 ml antibiotic medium 1 (Difco Laboratories) in petri dishes (90 mm) and Micrococcus luteus ATCC 9341 as test organism (Bauer et al., 1966, Coleman et al., 1995, Pizzimenti et al., 1987).

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  • Comparative pharmacokinetics of active alkaloids

    Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method. Chen Y(1), Li Y, Wang Y, Yang Q, Dong Y, Weng X, Zhu X, Wang Y, Gong Z, Zhang R.

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  • Pharmacokinetics of Isofraxidin in Rat Plasma after

    2007-9-1 · High-performance liquid chromatography coupled with solid phase extraction method was developed for determination of isofraxidin in rat plasma after oral administration of Acanthopanax senticosus extract (ASE), and pharmacokinetic parameters of isofraxidin either in ASE or pure compound were measured. The HPLC analysis was performed on a Dikma Diamonsil RP 18 column (4.6 …

    Get Price
  • Pharmacokinetics of Oral and Intravenous Omeprazole in ...

    2013-5-8 · (38). After oral administration the pharmacokinetic parame- ters determined included the observed peak concentration (C,,,], the time to reach the peak after dosing (t,,), and the bioavailability (F), which was calculated from the ratio of dose-normalized AUC values for oral and IV administration.

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  • Pharmacokinetics of Escalating Doses of Oral

    2017-3-28 · Psilocybin is a psychedelic tryptamine that has shown promise in recent clinical trials for the treatment of depression and substance use disorders. This open-label study of the pharmacokinetics of psilocybin was performed to describe the pharmacokinetics and safety profile of psilocybin in sequential, escalating oral doses of 0.3, 0.45, and 0.6 mg/kg in 12 healthy adults.

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  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Florfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio). Vet. Res. Forum. 8, …

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  • Determine ka from Oral Data - Method of Residuals

    Determining ka using the Method of Residuals Oral Dosing - Linear One Compartment A 25 mg oral dose of a drug was administered to a healthy volunteer. Blood samples were collected and plasma was separated from each blood sample and analyzed for drug concentration. The collected data are shown in …

    Get Price
  • Project: A pharmacokinetic study in rabbits after oral ...

    Project: A pharmacokinetic study in rabbits after oral administration of tilmicosin mixed in the feed. 01-SEP-02 – 30-NOV-02. Abstract A study was performed with 16 healthy New-Zealand white rabbits which were treated orally during five consecutive days with tilmicosin mixed in the feed at a dose rate of 200 mg tilmicosin/kg feed.

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  • Kinetics and intrapulmonary disposition of tilmicosin ...

    2010-5-18 · Tilmicosin (TIM, Pulmotil®) was administered to eight rabbits by oral gavage at a dose of 12.5 mg/kg body weight for 2, 5, and 7 days, and its plasma kinetics and intrapulmonary disposition were investigated. TIM concentrations in plasma samples collected after days 1 and 6 of treatment were measured by high-performance liquid chromatography with ultraviolet detection.

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  • Preparation and evaluation of tilmicosin-loaded ...

    After 24 hours, the medium was replaced with 100 μL of DMEM complete medium containing tilmicosin (final drug concentration: 32 μg/mL, 64 μg/mL, 128 μg/mL, 256 μg/mL, and 512 μg/mL). Cytotoxicity of the blank nanoparticle suspensions of the same volume was also conducted. After 24 hours of coincubation, cell viability was assessed by MTT ...

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  • Efficacy of Tylosin and Tilmicosin Against Experimental ...

    2019-3-14 · Also for tilmicosin, only a limited number of studies are available on the pharmacokinetics after oral administration in poultry. After a single oral administration of 30 mg/kg BW tilmicosin in chickens, the mean peak plasma concentration of tilmicosin in plasma was 2.12 lg/ml . A single oral dose of 50 mg/kg BW tilmicosin in fowl resulted in ...

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  • High-performance liquid chromatography

    High-performance liquid chromatography determination and pharmacokinetics of coumarin compounds after oral administration of Samul-Tang to rats. Hwang YH(1), Cho WK(1), Jang D(1), Ha JH(1), Ma JY(1). Author information: (1)Korean Medicine-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, South Korea.

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  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Florfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio). Vet. Res. Forum. 8, …

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  • Pharmacokinetics of metformin after intravenous and

    The kinetics of 14 C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9±1.61 ((ar X) ±SE), from which its elimination could be described using three-compartment open model.The elimination half-life from plasma was 1.7±0.1 h.

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  • (PDF) Pharmacokinetics and Bioequivalence of Two ...

    Norfloxacin was given directly into the crop using a thin plastic tube attached to a syringe for oral administration and in the right brachial vein for intravenous route. Food was withheld for 12 h before drug administration and was offered 6 h after drug administration. Water was provided ad libitum.

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  • Pharmacokinetics of Isofraxidin in Rat Plasma after

    Pharmacokinetics of Isofraxidin in Rat Plasma after Oral Administration of the Extract of Acanthopanax senticosus Using HPLC with Solid Phase Extraction Method . By Hui Sun, Haitao Lv, Yanmei Zhang, Xijun Wang, Kaishun Bi and Hongxin Cao. Cite .

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  • Pharmacokinetics and subjective effects of 1P‐LSD in ...

    The bioavailability of LSD after oral ingestion of 1P‐LSD was close to 100%. The psychosensory effects of 1P‐LSD and their time course were comparable to those seen after uptake of LSD in other studies which further supports the prodrug hypothesis. The 5D‐ASC scores were higher after oral compared with intravenous administration of 1P‐LSD.

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  • TOXICOLOGICAL EVALUATION OF TILMICOSIN AFTER

    2018-11-13 · Preparation of tilmicosin concentrations: The 20 grams of tilmicosin sodium phosphate powder was dissolved in 50 ml of distilled water (200mg/0.5ml). The dilutions i.e. 100, 50, 25, 12.5 and 6.25 were prepared by twofold serial dilution method from the stock solution (200mg/0.5ml). Experimental Protocol: One day old broiler chicks

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  • Preparation and evaluation of tilmicosin-loaded ...

    After 24 hours, the medium was replaced with 100 μL of DMEM complete medium containing tilmicosin (final drug concentration: 32 μg/mL, 64 μg/mL, 128 μg/mL, 256 μg/mL, and 512 μg/mL). Cytotoxicity of the blank nanoparticle suspensions of the same volume was also conducted. After 24 hours of coincubation, cell viability was assessed by MTT ...

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  • Efficacy of Tylosin and Tilmicosin Against Experimental ...

    2019-3-14 · Also for tilmicosin, only a limited number of studies are available on the pharmacokinetics after oral administration in poultry. After a single oral administration of 30 mg/kg BW tilmicosin in chickens, the mean peak plasma concentration of tilmicosin in plasma was 2.12 lg/ml . A single oral dose of 50 mg/kg BW tilmicosin in fowl resulted in ...

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  • Pharmacokinetics of meloxicam, carprofen, and

    2021-4-12 · Plasma concentrations of MLX, CRP, and TA were determined using HPLC-UV and analyzed by non-compartmental method. The t 1/2ʎz and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The V darea /F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA ...

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  • Pharmacokinetics and pharmacogenetics of DA-8031

    The mean apparent clearance of DA-8031 at steady state was 46.9 and 45.0 L/h after multiple oral doses of 20 and 30 mg, respectively, but decreased to 25.8 L/h after multiple doses of 40 mg. The mean accumulation indexes were 2.3, 2.4 and 2.8 after multiple oral doses of …

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  • Pharmacokinetics of indomethacin - Alván - 1975 -

    All analyses were carried out using a new mass fragmentographic method. After oral and rectal doses the plasma decay of indomethacin was biphasic, and the data were interpreted according to a 2-compartment open model. The half-life of the β-phase varied between 2.6 and 11.2 hr.

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  • Pharmacokinetics of Oral and Intravenous Omeprazole in ...

    2013-5-8 · (38). After oral administration the pharmacokinetic parame- ters determined included the observed peak concentration (C,,,], the time to reach the peak after dosing (t,,), and the bioavailability (F), which was calculated from the ratio of dose-normalized AUC values for oral and IV administration.

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  • Pharmacokinetics and subjective effects of 1P‐LSD in ...

    The bioavailability of LSD after oral ingestion of 1P‐LSD was close to 100%. The psychosensory effects of 1P‐LSD and their time course were comparable to those seen after uptake of LSD in other studies which further supports the prodrug hypothesis. The 5D‐ASC scores were higher after oral compared with intravenous administration of 1P‐LSD.

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  • Determination and pharmacokinetics study of

    2019-6-24 · Oxyclozanide is an anthelmintic drug that is widely used to treat fasciolosis. However, the pharmacokinetics of oxyclozanide in cattle are not yet clearly understood. The present study was designed to develop a sensitive method to determine oxyclozanide levels in cattle plasma using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and to study its pharmacokinetics ...

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