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lowest cost of comparative pharmacokinetics of florfenicol

  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At …

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  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Ismail, M. & El-Kattan, Y. A. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. Br. Poult. Sci. 50, 144–149 (2009). CAS Article Google Scholar

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  • Pharmacokinetics of florfenicol after intravenous and ...

    2013-10-1 · Florfenicol, is a broad spectrum antimicrobial agent with wide tissue distribution commonly used to treat camelids. To address the lack of drug disposition data for florfenicol in llamas, we evaluated the pharmacokinetics after 20 mg/kg intravenous (i.v.) and intramuscular (i.m.) dosing. Serum concentrations were determined using a HPLC-UV assay and pharmacokinetic analysis was …

    Get Price
  • Pasteurella multocida‐infected Gaoyou ducks

    Comparative pharmacokinetics of florfenicol in healthy and Pasteurella multocida ‐infected Gaoyou ducks Weixuan Lan 1* | Xia Xiao 1,2,3* | Yongjia Jiang 1 | Lijie Jiang 1 | Xu Zhao 1 |

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  • Florfenicol pharmacokinetics in healthy adult alpacas ...

    2011-7-8 · Florfenicol decreased the following hematological parameters after repeated administration between weeks 0 and 3: total protein (6.38 vs. 5.61 g/dL, P < 0.0001), globulin (2.76 vs. 2.16 g/dL, P < 0.0003), albumin (3.61 vs. 3.48 g/dL, P = 0.0038), white blood cell count (11.89 vs. 9.66 × 10 3 /μL, P < 0.044), and hematocrit (27.25 vs. 24.88%, P < 0.0349). Significant clinical illness was observed in one …

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    The mobile phase was filtered through a 0.2 µm Millipore filter and degassed using helium and sonication (5 min). The flow rate was 1 ml min -1 , giving elution times of 3.3 min (thiamphenicol), 4.7 min (florfenicol amine) and 5.6 min (florfenicol).Pharmacokinetic analysis.

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  • Comparative pharmacokinetics of oxytetracycline in

    2018-10-1 · Feng et al. (2008) demonstrated that florfenicol tissue drug concentrations of seawater tilapia were lower than that in freshwater tilapia; and the elimination of florfenicol in seawater tilapia was more rapid than that in freshwater tilapia. This necessitates studying the effect of factors on PK of OTC in tilapia in order to determine optimum dosage regimen for achieving therapeutic success and …

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  • Estimating the comparative clinical and economic ...

    Depending on the study selected as the basis for the efficacy evaluation, cost savings with tulathromycin were calculated in the CM between US21.00 and 47.86 (vs. florfenicol) and 11.37 and 72.64 (vs. tilmicosin); cost savings in the TM ranged between 28.47 and 143.87 (vs. florfenicol) and 7.75 and 84.91 (vs. tilmicosin) as well as between 23.22 and 47.82 (vs. enrofloxacin), with the ranges …

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  • A comparison of florfenicol and tilmicosin for the ...

    In the economic analysis, there was an advantage of 18.83 CDN per animal in the florfenicol group. The results of this study indicate that florfenicol is superior to tilmicosin for the treatment of UF because of lower chronicity, wastage, overall mortality, and BRD mortality rates.

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  • Comparison of Active Drug Concentrations in the

    2016-2-12 · The objective of this study was to investigate pharmacokinetics of four antimicrobials administered to calves for treatment and control of BRD. These four drugs (enrofloxacin, florfenicol, ceftofur crystalline-free acid, and tulathromycin) are commonly used in cattle and represent four distinct classes of antimicrobials.

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  • Florfenicol pharmacokinetics in healthy adult alpacas ...

    2012-8-1 · Holmes, K., Bedenice, D., Papich, M. G. Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection. J. vet. Pharmacol. Therap. 35, 382–388. A single dose of florfenicol (Nuflor®) was administered to eight healthy adult alpacas at 20 mg/kg intramuscular (i.m.) and 40 mg/kg subcutaneous (s.c.) using a randomized, cross‐over design, and 28‐day ...

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Ole Samuelsen. ø. Bergh. Ole Samuelsen. ø. Bergh. Related Papers. Efficacy of orally administered flumequine in the treatment of vibriosis caused by …

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  • Pharmacokinetics of florfenicol, thiamphenicol, and ...

    2007-4-1 · The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w. and their concentrations in plasma samples were assayed using the same validated high‐performance liquid ...

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  • A comparison of florfenicol and tilmicosin for the ...

    In the economic analysis, there was an advantage of 18.83 CDN per animal in the florfenicol group. The results of this study indicate that florfenicol is superior to tilmicosin for the treatment of UF because of lower chronicity, wastage, overall mortality, and BRD mortality rates.

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  • Multidose pharmacokinetics of orally administered ...

    2013-10-1 · The pharmacokinetics of florfenicol observed in this multiple dose study support its label claim for control of mortality associated with E. ictaluri and F. columnare , and the plasma values in catfish exceed the florfenicol MIC values for these pathogens when administered at 10 mg/kg bw one time a day for 10 days.

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  • Salinity-dependent pharmacokinetics of florfenicol in

    2020-3-30 · The serum concentration-time profiles of FF after IV administration at 4 different salinity levels (2, 4, 8, and 15 ppt) were shown in Fig. 1 and the PK parameters were presented in Table 1.As a result of increasing water salinity from 2 to 15 ppt, the AUC was significantly decreased from 326.19 to 267.74 h·μg/mL and the CL was significantly increased from 0.047 to 0.056 L/kg/h.

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  • In vivo pharmacokinetic/Pharmacodynamic modeling

    2018-11-29 · Koc F, Uney K, Ozturk M, Kadioglu Y, Atila A. Pharmacokinetics of florfenicol in the plasma of Japanese quail. N Z Vet J. 2009;57(6):388–91. CAS Article Google Scholar 13. Aliabadi FS, Ali BH, Landoni MF, Lees P. Pharmacokinetics and PK-PD modelling of …

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  • Pig Clinical Pharmacology - Swine Antimicrobial ...

    2020-5-1 · Florfenicol is widely used to control diseases in aquatic animals, and is used extensively to treat streptococcosis—caused by Streptococcus agalactiae—in the commercially important fish tilapia.There are known issues with the development of florfenicol resistance in Streptococcus agalactiae, but the underlying resistance mechanisms are not clear, a situation currently preventing optimal ...

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  • Comparative transcriptome profiling reveals a

    2012-11-9 · Table 1 also shows the comparative MPC distribution data for the M. haemolytica strains against the 5 antimicrobial agents. A calculation of the MPC 50 and MPC 90 values are also shown – the drug concentration inhibiting the growth of the least susceptible cells present in the high density populations for 50% and 90% respectively of the strains tested. . For testing ceftiofur, 41 random ...

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  • Pharmacokinetics of florfenicol, thiamphenicol, and ...

    2007-4-1 · The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w. and their concentrations in plasma samples were assayed using the same validated high‐performance liquid ...

    Get Price
  • Florfenicol pharmacokinetics in healthy adult alpacas ...

    2012-8-1 · Holmes, K., Bedenice, D., Papich, M. G. Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection. J. vet. Pharmacol. Therap. 35, 382–388. A single dose of florfenicol (Nuflor®) was administered to eight healthy adult alpacas at 20 mg/kg intramuscular (i.m.) and 40 mg/kg subcutaneous (s.c.) using a randomized, cross‐over design, and 28‐day ...

    Get Price
  • A comparison of florfenicol and tilmicosin for the ...

    Adams PE, Varma KJ, Powers TE, Lamendola JF. Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses. Am J Vet Res. 1987 Dec; 48 (12):1725–1732. Hoar BR, Jelinski MD, Ribble CS, Janzen ED, Johnson JC.

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  • Poster Section 11: Pharmacokinetics - 2018 - Journal

    2018-6-14 · Introduction: Florfenicol (FF) is an antimicrobial widely used in commercial poultry farms to treat a broad range of bacterial infections. Since it is administered in drinking water, FF pharmacokinetics may be affected by numerous factors, including gastrointestinal physiology, stress, disease or diet.

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  • Estimating the comparative clinical and economic ...

    Depending on the study selected as the basis for the efficacy evaluation, cost savings with tulathromycin were calculated in the CM between US21.00 and 47.86 (vs. florfenicol) and 11.37 and 72.64 (vs. tilmicosin); cost savings in the TM ranged between 28.47 and 143.87 (vs. florfenicol) and 7.75 and 84.91 (vs. tilmicosin) as well as ...

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  • Pharmacodynamics of Ceftiofur Selected by Genomic

    2020-3-31 · Ceftiofur sodium has an antimicrobial mechanism in common with the one of the identified therapeutic targets (PBP 2A) from the genomic analysis, and for comparative purposes, florfenicol was used. According to the MIC and MBC testing results, all isolates were completely sensitive to ceftiofur and florfenicol with MICs ranging from 0.0039 to 1 ...

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  • Development and validation of a method for

    2021-3-30 · Florfenicol is a chloramphenicol antibiotic that plays an essential role on bacteriostasis. Long-term use of florfenicol in livestock and poultry can cause immunetoxicity and reproductive toxicity and the consumption of animal-derived products with excessive residues of florfenicol will pose a certain threat to human health. To study residue depletion of oral florfenicol in chickens, 48 ...

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  • Acute Toxicity and Risk Assessment of Florfenicol for

    2020-10-8 · The aim of this study was to determine the median lethal concentration (LC50−96h), effective concentration (EC50−96h), risk assessment, and development of Nile tilapia Oreochromis niloticus larvae submitted to florfenicol (FF) exposure. Fish (n = 147; 8.6 ± 0.6 mg; 7 fish/aquarium) were randomly distributed in 21 aquaria (1 L) and exposed to five concentrations of FF 58.73; 131.31; 198.96 ...

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  • Pharmacokinetics/Pharmacodynamics models of

    The advantage of an in ex vivo PK/PD models is not only its ability to reflect the real PK process in vivo but also its capacity to reduce the number of animals used and the cost of the experiment . At present, in ex vivo PK/PD models have become one of the more common methods to study PK/PD of veterinary antimicrobial agents [ 34 ].

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  • (PDF) Comparative Pharmacokinetics of Gentamicin in

    The elimination of gentamicin residues in eggs was reported by Filazi et al. 8 . When administered to laying hens via IM or SC routes, gentamicin was deposited in egg yolk and albumen, with residues persisting for longer periods in the yolk 8,9 .Although the aminoglycosides have been extensively reviewed, few studies on the pharmacokinetics of ...

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  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At …

    Get Price
  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Ismail, M. & El-Kattan, Y. A. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. Br. Poult. Sci. 50, 144–149 (2009). CAS Article Google Scholar

    Get Price
  • Pharmacokinetics of florfenicol after intravenous and ...

    2013-10-1 · Florfenicol, is a broad spectrum antimicrobial agent with wide tissue distribution commonly used to treat camelids. To address the lack of drug disposition data for florfenicol in llamas, we evaluated the pharmacokinetics after 20 mg/kg intravenous (i.v.) and intramuscular (i.m.) dosing. Serum concentrations were determined using a HPLC-UV assay and pharmacokinetic analysis was …

    Get Price
  • Florfenicol pharmacokinetics in healthy adult alpacas ...

    2011-7-8 · Florfenicol decreased the following hematological parameters after repeated administration between weeks 0 and 3: total protein (6.38 vs. 5.61 g/dL, P < 0.0001), globulin (2.76 vs. 2.16 g/dL, P < 0.0003), albumin (3.61 vs. 3.48 g/dL, P = 0.0038), white blood cell count (11.89 vs. 9.66 × 10 3 /μL, P < 0.044), and hematocrit (27.25 vs. 24.88%, P < 0.0349). Significant clinical illness was observed in one …

    Get Price
  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    The mobile phase was filtered through a 0.2 µm Millipore filter and degassed using helium and sonication (5 min). The flow rate was 1 ml min -1 , giving elution times of 3.3 min (thiamphenicol), 4.7 min (florfenicol amine) and 5.6 min (florfenicol).Pharmacokinetic analysis.

    Get Price
  • Estimating the comparative clinical and economic ...

    Depending on the study selected as the basis for the efficacy evaluation, cost savings with tulathromycin were calculated in the CM between US21.00 and 47.86 (vs. florfenicol) and 11.37 and 72.64 (vs. tilmicosin); cost savings in the TM ranged between 28.47 and 143.87 (vs. florfenicol) and 7.75 and 84.91 (vs. tilmicosin) as well as between 23.22 and 47.82 (vs. enrofloxacin), with the ranges …

    Get Price
  • Comparison of Active Drug Concentrations in the

    2016-2-12 · The objective of this study was to investigate pharmacokinetics of four antimicrobials administered to calves for treatment and control of BRD. These four drugs (enrofloxacin, florfenicol, ceftofur crystalline-free acid, and tulathromycin) are commonly used in cattle and represent four distinct classes of antimicrobials.

    Get Price
  • Salinity-dependent pharmacokinetics of florfenicol in

    2020-3-30 · Salinity-dependent pharmacokinetics of florfenicol was revealed. At higher salinity levels, the drug elimination was more rapid. Nile tilapia at 15 ppt required almost 50% …

    Get Price
  • Poster Section 11: Pharmacokinetics - 2018 - Journal

    2018-6-14 · Introduction: Florfenicol (FF) is an antimicrobial widely used in commercial poultry farms to treat a broad range of bacterial infections. Since it is administered in drinking water, FF pharmacokinetics may be affected by numerous factors, including gastrointestinal physiology, stress, disease or diet.

    Get Price
  • Comparative transcriptome profiling reveals a

    2020-5-1 · Florfenicol is widely used to control diseases in aquatic animals, and is used extensively to treat streptococcosis—caused by Streptococcus agalactiae—in the commercially important fish tilapia. There are known issues with the development of florfenicol resistance in Streptococcus agalactiae , but the underlying resistance mechanisms are not clear, a situation currently preventing optimal …

    Get Price
  • Frontiers | Comparative Pharmacokinetics and

    2019-6-11 · Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. ...

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  • Semi-Mechanistic Modeling of Florfenicol Time-Kill

    2019-5-13 · Salmonid Rickettsial Septicemia (SRS) is the disease of greatest economic importance in the Chilean salmon farming industry, causing high mortality in fish during the final stage of their productive cycle at sea. Since current, commercially available vaccines have not demonstrated the expected efficacy levels, antimicrobials, most commonly florfenicol, are still the main resource for the ...

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  • Optimization of florfenicol dose against Piscirickettsia ...

    2013-12-1 · Comparative Clinical Studies Considered in the Treatment Model. Ten peer-reviewed articles were identified, including 2 systematic reviews (O'Connor et al., 2013; Wellman and O'Connor, 2007) and the following 8 articles (17 studies) reporting comparative efficacy of tulathromycin for treatment of clinically apparent BRD in feedlot cattle (comparator or comparators and number of sites): Van ...

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  • Estimating the comparative clinical and economic ...

    Pharmacokinetics of florfenicol in veal calves. J Vet Pharmacol Ther 1986; 9(4):412-25. [ Links ] 10. Drago L, De Vecchi E, Fassina MC, Mombelli B, Tocalli L, Gismondo MR. Comparative in vitro activity of thiamphenicol-glycinate and thiamphenicol - glycinate - acetylcysteinate and other antimicrobials against respiratory pathogens.

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  • Florfenicol concentrations in milk of lactating cows ...

    2020-10-15 · Wilson WD, Mihalyi JE (1998) Comparative pharmacokinetics of ceftiofur in neonatal foals and adult horses. In: Neonatal Septicemia Workshop II. Davis, p 1. 40. ElSayed M, ElKomy A, Elbarawy A, Ibrahim D (2015) Pharmacokinetics and tissue residues of ceftiofur in normal and Escherichia coli infected chickens. J Physiol Pharmacol Adv 5:574.

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  • Pharmacokinetic and pharmacodynamic integration

    2017-11-14 · Florfenicol, the antibacterial component of this new product, is a broad-spectrum antibiotic and fluorinated derivative of chloramphenicol and thiamphenicol. Like chloramphenicol and thiamphenicol, florfenicol is a potent inhibitor of microbial protein synthesis that exerts its effect via irreversibly binding the 50S subunit of the bacterial ...

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  • Evaluation of a single‐administration ototopical

    2018-10-24 · The aim of this study was to optimize the dosage regimen of tylosin against S.suis in Pigs using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The antibacterial activity of tylosin against S.suis CVCC606 was investigated in Mueller Hinton (MH) broth and serum. The objectives of this investigation were to study the PD data of tylosin against S.suis CVCC606 and the PK data of tylosin …

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  • Pharmacokinetic-pharmacodynamic modeling of

    Fax +962 2 7201075. Email [email protected] Introduction: Piperine, the bioactive compound of black pepper, and warfarin are metabolized by cytochrome P450 enzymes and are both highly plasma protein-bound compounds. In this study, we evaluated the effect of co-administered piperine on the pharmacokinetics and anticoagulation of warfarin in rats.

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  • Nuflor (Florfenicol) Solution for Cattle Merck - Safe ...

    Nuflor (Florfenicol) Injectable Solution for Cattle is an antibiotic indicated for the treatment of bovine respiratory disease (BRD) and foot rot, and for the control of respiratory disease in cattle at high risk for developing BRD. Each ml of Nuflor Injectable Solution contains 300 mg florfenicol.

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  • Comparison of pharmacokinetics and efficacy of oral and ...

    – Compare pharmacokinetics of oral and injectable drugs – Describe the impact of malnutrition on drug pharmacokinetics – Compare the effectivenesss of oral and injectable drugs in randomized clinical trials – Compare the cost of oral and injectable drugs

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  • Continuous infusion of lorazepam versus medazolam

    The fact that there are many factors influencing midazolam pharmacokinetics may explain the more difficult management of desired sedation levels. The equipotent dose of 10 mg of midazolam proved to be 0.7 mg of lorazepam in long-term sedation. The average cost for therapy with midazolam was approximately ten times more than that with lorazepam.

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  • Evaluation of a single‐administration ototopical

    2017-11-14 · Florfenicol, the antibacterial component of this new product, is a broad-spectrum antibiotic and fluorinated derivative of chloramphenicol and thiamphenicol. Like chloramphenicol and thiamphenicol, florfenicol is a potent inhibitor of microbial protein synthesis that exerts its effect via irreversibly binding the 50S subunit of the bacterial ...

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  • Comparative biomembrane permeation of tacrine

    Tacrine (THA), a centrally acting acetylcholine-esterase inhibitor, is presently administered perorally for the treatment of Alzheimer's disease (AD). However, its low bioavailablity (i.e., 17%) and short half-life (2-4 h) demand the search for alternative routes of administration. The primary objec …

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  • Comparative intestinal bacteria-associated ...

    2017-9-11 · Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out sample preparation and LC-MS/MS†

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  • Once-monthly paliperidone injection for the

    2010-9-7 · Paliperidone palmitate is a new long-acting antipsychotic injection for the treatment of acute and maintenance therapy in schizophrenia. Paliperidone (9-hydroxyrisperidone) is the major active metabolite of risperidone and acts at dopamine D 2 and serotonin 5HT 2A receptors. As with other atypical antipsychotics, it exhibits a high 5HT 2A:D 2 affinity ratio.

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  • A comparative study of evaluating missing value

    2021-1-19 · A random forest-based imputation method consistently outperformed other popular methods by achieving the lowest NRMSE, high amount of TPs with the …

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  • Nuflor (Florfenicol) Solution for Cattle Merck - Safe ...

    Nuflor (Florfenicol) Injectable Solution for Cattle is an antibiotic indicated for the treatment of bovine respiratory disease (BRD) and foot rot, and for the control of respiratory disease in cattle at high risk for developing BRD. Each ml of Nuflor Injectable Solution contains 300 mg florfenicol.

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  • The pharmacokinetic/pharmacodynamic paradigm for ...

    CLSI document M100-S22 . 2012 . 16. Blondeau JM , Borsos S , Blondeau LD , Blundeau BJ , Hesje CE . Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica . Vet Microbiol . 2012 ; 160 ( 1-2 ): 85 ...

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  • Pharmacokinetics (PK), pharmacodynamics (PD), and

    2020-7-22 · Comparative PK/PD characteristics of the three echinocandins. PK/PD indices for borderline susceptible isolates and percentage of patients that attained preclinical PK/PD targets for stasis of C. albicans , C. glabrata and C. parapsilosis in our patient cohort (box-and-whisker plots).

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  • Comparative pharmacokinetics of the three

    2016-6-14 · Table 2: Details of currently available systems for the detection of microorganisms. Pharmacodynamics of Antipsychotics. Action of Antipsychotics on Different Types of Neurotransmitter Receptor. Relevance to side effects first generation antipsychotics, as exemplified by chlorpromazine, have been structurally modified to produce drugs with greater affinity for dopamine receptors while ...

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  • First Generation Antipsychotics: Pharmacokinetics ...

    2019-8-21 · Sparreboom, A. et al. Comparative preclinical and clinical pharmacokinetics of a Cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in Cremophor (Taxol ...

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  • A Review of Enrofloxacin for Veterinary Use

    2017-6-23 · The most widely used measure of potency of antimicrobial drugs is Minimum Inhibitory Concentration (MIC). MIC is usually determined under standardised conditions in broths formulated to optimise bacterial growth on a species-by-species basis. This ensures comparability of data between laboratories. However, differences in values of MIC may arise between broths of differing chemical …

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  • A Systematic Review on Traditional Uses, Sources ...

    2021-6-22 · Antimicrobial pharmacokinetics–pharmacodynamics is influenced by patient, microbial and drug factors 14.Many factors that influence therapy are difficult to quantify and determine in vivo, such ...

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  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At …

    Get Price
  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Ismail, M. & El-Kattan, Y. A. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. Br. Poult. Sci. 50, 144–149 (2009). CAS Article Google Scholar

    Get Price
  • Pharmacokinetics of florfenicol after intravenous and ...

    2013-10-1 · Florfenicol, is a broad spectrum antimicrobial agent with wide tissue distribution commonly used to treat camelids. To address the lack of drug disposition data for florfenicol in llamas, we evaluated the pharmacokinetics after 20 mg/kg intravenous (i.v.) and intramuscular (i.m.) dosing. Serum concentrations were determined using a HPLC-UV assay and pharmacokinetic analysis was …

    Get Price
  • Florfenicol pharmacokinetics in healthy adult alpacas ...

    2011-7-8 · Florfenicol decreased the following hematological parameters after repeated administration between weeks 0 and 3: total protein (6.38 vs. 5.61 g/dL, P < 0.0001), globulin (2.76 vs. 2.16 g/dL, P < 0.0003), albumin (3.61 vs. 3.48 g/dL, P = 0.0038), white blood cell count (11.89 vs. 9.66 × 10 3 /μL, P < 0.044), and hematocrit (27.25 vs. 24.88%, P < 0.0349). Significant clinical illness was observed in one …

    Get Price
  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    The mobile phase was filtered through a 0.2 µm Millipore filter and degassed using helium and sonication (5 min). The flow rate was 1 ml min -1 , giving elution times of 3.3 min (thiamphenicol), 4.7 min (florfenicol amine) and 5.6 min (florfenicol).Pharmacokinetic analysis.

    Get Price
  • Estimating the comparative clinical and economic ...

    Depending on the study selected as the basis for the efficacy evaluation, cost savings with tulathromycin were calculated in the CM between US21.00 and 47.86 (vs. florfenicol) and 11.37 and 72.64 (vs. tilmicosin); cost savings in the TM ranged between 28.47 and 143.87 (vs. florfenicol) and 7.75 and 84.91 (vs. tilmicosin) as well as between 23.22 and 47.82 (vs. enrofloxacin), with the ranges …

    Get Price
  • Comparison of Active Drug Concentrations in the

    2016-2-12 · The objective of this study was to investigate pharmacokinetics of four antimicrobials administered to calves for treatment and control of BRD. These four drugs (enrofloxacin, florfenicol, ceftofur crystalline-free acid, and tulathromycin) are commonly used in cattle and represent four distinct classes of antimicrobials.

    Get Price
  • Salinity-dependent pharmacokinetics of florfenicol in

    2020-3-30 · Salinity-dependent pharmacokinetics of florfenicol was revealed. At higher salinity levels, the drug elimination was more rapid. Nile tilapia at 15 ppt required almost 50% …

    Get Price
  • Poster Section 11: Pharmacokinetics - 2018 - Journal

    2018-6-14 · Introduction: Florfenicol (FF) is an antimicrobial widely used in commercial poultry farms to treat a broad range of bacterial infections. Since it is administered in drinking water, FF pharmacokinetics may be affected by numerous factors, including gastrointestinal physiology, stress, disease or diet.

    Get Price
  • Comparative transcriptome profiling reveals a

    2020-5-1 · Florfenicol is widely used to control diseases in aquatic animals, and is used extensively to treat streptococcosis—caused by Streptococcus agalactiae—in the commercially important fish tilapia. There are known issues with the development of florfenicol resistance in Streptococcus agalactiae , but the underlying resistance mechanisms are not clear, a situation currently preventing optimal …

    Get Price
  • Comparison of pharmacokinetics and efficacy of oral and ...

    – Compare pharmacokinetics of oral and injectable drugs – Describe the impact of malnutrition on drug pharmacokinetics – Compare the effectivenesss of oral and injectable drugs in randomized clinical trials – Compare the cost of oral and injectable drugs

    Get Price
  • A Comparative Study of the Anticlostridial Activity of ...

    The results show that NPV had the lowest MIC (0.25 mg mL – 1) since it had a high inhibition percentage of 97.57%, even at half of the MIC (0.125 mg mL – 1). The MICs of enramycin and florfenicol were 0.5 mg mL – 1. The other tested antibiotics showed higher MIC values.

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  • A Perspective on Principles of Comparative Cost ...

    A Perspective on Principles of Comparative Cost-Effectiveness Studies for Pharmacotherapy of Chronic Diseases Pendar Farahani, MD, MSc C hronic diseases such as heart disease and diabetes are the leading causes of disabil - ity and death in the United States. Seventy percent of all deaths in the United States annually are the result

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  • Preclinical Development of Crocus sativus-Based

    2021-3-12 · The comparative oral pharmacokinetics of IIIM-141-CEF and CSE-2 was then performed. The plasma samples were analyzed for crocin-1 and crocetin contents using a fit-for-purpose LC–MS/MS method with a lower limit of quantification of 9.95 ng/mL.

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  • Drug Metabolism and Pharmacokinetics, the Blood

    Summary: The worldwide market for therapies for CNS disorders is worth more than 50 billion and is set to grow substantially in the years ahead. This is because: 1) the incidence of many CNS disorders (e.g., Alzheimer’s disease, stroke, and Parkinson’s disease) increase exponentially after age 65 and 2) the number of people in the world over 65 is about to increase sharply because of a ...

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  • Pharmacokinetics and Pharmacodynamics of Insulin

    OBJECTIVE To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg s.c.), either in the evening (2200 h) or the morning (1000 h). RESULTS …

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  • Pharmacokinetics and Bioavailability Study of a ...

    2003-1-27 · Prednisolone is a well-known corticosteroid used extensively for its anti-inflammatory and immunosuppressive properties. 1 It is a potent synthetic glucocorticoid that is the active metabolite of its prodrug prednisone. 2 Chemically, it is known as 11βb, 17, 21-trihydoxypregna-1,4-diene-3,20-dione, CAS 50-24-8. 1 Prednisolone has been listed by World Health Organization as an essential ...

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  • Behavior of horizontal sub-surface flow wetlands as an ...

    Oxytetracycline and florfenicol are two of the most widely used antibiotics for the control of bacterial diseases in fish 8-11, Carraschi et al. 8 monitored florfenicol in 8 effluents from animal farms, 18 river water samples, and 8 fish pond water samples, detecting averages of 0.95, 2.40, and 2.84 μg L, respectively. As the waters of the ...

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  • Doxorubicin | C27H29NO11 - PubChem

    2011-9-9 · A Comparative Review of Oxybutynin Chloride Formulations Pharmacokinetics_医药卫生_专业资料 TREATMENT UPDATE A Comparative Review of Oxybutynin Chloride Formulations: Pharmacokinetics and Therapeutic Efficacy in Overactive Bladder Michael J.

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