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design of tilmicosin solution treated on viral respiratory disease

  • Efficacy of tilmicosin for on-arrival treatment of bovine ...

    long-acting oxytetracycline, tilmicosin, tulathromycin, gamithromycin, and tildipirosin, are used in fall-placed feedlot calves to reduce morbidity and mortality from bovine respiratory disease (BRD) and to improve perfor­ mance.14'9 In recent years, BRD morbidity and mortality rates in southern Alberta have increased in winter-

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  • Comparative Efficacy of Tulathromycin, Tilmicosin, and ...

    Tilmicosin, and Florfenicol in the Treatment of Bovine Respiratory Disease in Stocker Cattle* Robert G. Nutsch, DVM, MS, MBAa Terry L. Skogerboe, DVM, MBAa Kathleen A. Rooney, MS, DVMa

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  • A coinparison of tilmicosin to gainithromycin for on ...

    moderate risk of bovine respiratory disease (BRD) to compare the efficacy of gamithromycin to tilmicosin for metaphylactic treatment of BRD. First-pull treatment rates for BRD were significantly lower (P = 0.01) in calves in the gamithromycin group than in the tilmicosin group. There were no other significant differences in health or

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  • Effects of nasal instillation of a nitric oxide-releasing ...

    2017-12-1 · A nitric oxide releasing solution (NORS) has been developed for control of bovine respiratory disease (BRD). Effects on the nasopharyngeal microbiota of nasal instillation of NORS or parenteral tilmicosin were compared.

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  • Comparative efficacy of tilmicosin, florfenicol, and ...

    benefit of tilmicosin versus florfenicol and florfenicol­ flunixin meglumine was based on the difference in treat­ ment cost between the 3 drugs. Using current market prices and a treatment weight of828 lb (376 kg), the cost of treatment with tilmicosin was 15.85 CAN less per head compared to treatment with florfenicol, and 15.90

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  • Comparison of treatment protocols for bovine

    2019-6-1 · Crossbred male calves (n = 176; BW = 232 ± 1.6 kg) were stratified by BW and castration status and assigned randomly to 1 of 2 treatments in a randomized complete block design. Calves were administered either 2.5 mg/kg of BW of tulathromycin (TUL, Draxxin, Zoetis, Florham Park, NJ) with a 7-d post-metaphylactic treatment or 10 mg/kg of BW of ...

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  • Comparative Efficacy of Tulathromycin versus Florfenicol ...

    and Texas study locations, tilmicosin was given SC at 10 mg/kg body weight. Cure rate, a derived variable that included assessments of mortality, rectal tem- perature, and attitude and respiratory ...

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  • Bovine respiratory disease: Efficacy of different ...

    2012-3-1 · Bovine respiratory disease (BRD) is an important economic problem in veal production in Switzerland and other European countries. This production system comprises the transportation of young calves from their birth farms to fattening units where individuals from several different breeders are mingled (Ganheim et al., 2007).

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  • The effect of antimicrobial treatment and preventive ...

    Feedlot calves (n = 3784) were systematically randomized and allocated in a 2 × 2 factorial study to receive metaphylactic oxytetracycline (OTC) on arrival or no antimicrobial, as well as florfenicol once subcutaneously or twice intramuscularly (48 h apart) if diagnosed with bovine respiratory disease (BRD). Calves of different treatment groups were comingled and followed from placement to re-implantation …

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  • Evolving views on bovine respiratory disease: An

    2016-11-1 · Introduction. Bovine respiratory disease (BRD) is one of the most commonly diagnosed causes of morbidity and mortality in cattle, both within large feedlots and traditional, smaller, pasture-based husbandry systems (Edwards, 2010, Murray et al, 2016).The pathogenesis of BRD is often driven by complex interactions of factors associated with the animal, the pathogen and the environment …

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  • Comparative effects of therapeutic programs on bovine ...

    2016-12-11 · Key ords:w bovine respiratory disease , ceftiofur crystalline free acid , feedlot , tilmicosin , ulathrom t cin y INTRODUCTION In the United States during 2010, 25.6% of total cattle death loss was due to bovine respiratory disease (BRD), representing a 4.28 bil-lion loss to the cattle industry, with overall treatment costs estimated to

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  • Efficacy of Tylosin and Tilmicosin Against

    2019-3-14 · Mycoplasma gallisepticum, the cause of chronic respiratory disease, remains one of the most important pathogens in the poultry industry. Controlling the impact of this disease is done by eradication of positive breeder flocks or by vaccination and medication. Tylosin and tilmicosin are often used in medication programs. However, recent data on the in vivo efficacy of these macrolide ...

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  • Field Efficacy Study of Gamithromycin for the Control of ...

    2021-3-15 · had been treated with antimicrobials within 30 days prior to enrollment, or had transit time to the study site in excess of 24 hours were excluded. Processing Cattle at the Texas site were received on Day -1 and processed on Day 0. At processing, each animal received a uniquely numbered ear tag. A viral respiratory vaccine (Reli-

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  • The effect of antimicrobial treatment and preventive ...

    Feedlot calves (n = 3784) were systematically randomized and allocated in a 2 × 2 factorial study to receive metaphylactic oxytetracycline (OTC) on arrival or no antimicrobial, as well as florfenicol once subcutaneously or twice intramuscularly (48 h apart) if diagnosed with bovine respiratory disease (BRD).Calves of different treatment groups were comingled and followed from placement to re ...

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  • (PDF) Bovine respiratory disease: Efficacy of

    Study design The study of Wettstein and Frey (2004) on respiratory pathogens isolated from different animal species showed All procedures, in accordance with the Swiss guide- that 50% of 20 bovine M. haemolytica isolates were mul- lines for animal welfare, were approved by the Animal tiresistant to tetracycline, ampicillin, and streptomycin.

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  • Disease transmission through expiratory aerosols

    2021-1-12 · In this paper, a detailed analysis of the airborne transmission of respiratory aerosols is conducted using the experimental measurement and computational fluid dynamics. The transmission on an urban bus is studied to identify the transmission mechanisms and to assess strategies to reduce risk.

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  • Method for treating bacterial infections in horses or

    2004-10-28 · (xiii) Analyze the resulting solution for tilmicosin using the HPLC method described above. The above analysis showed that tilmicosin, when administered using the compositions of the invention at a dose of 45 mg/kg or 75 mg/kg, was present in the lung tissue of the pigs at a concentration ranging from about 6.75 to 20.5 μg/g of lung tissue.

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  • Advances in vaccine delivery systems against viral ...

    2021-3-10 · MERS-CoV, which was first identified in Saudi Arabia in 2012, is a viral respiratory disease caused by coronavirus . More than 2000 cases MERS-CoV infection, which has typical symptoms including fever, cough, and shortness of breath, have been reported by WHO since September 2012 in around 27 countries .

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  • Inactivation of severe acute respiratory syndrome ...

    2020-4-20 · Severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a member of the coronavirus family. Coronavirus infections in humans are typically associated with respiratory illnesses; however, viral RNA has been isolated in serum from infected patients.

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  • Impact of Coronavirus Disease 2019 Pandemic on

    2021-6-2 · Centers for Disease Control and Prevention (CDC) estimates that close to 2.4 million Americans are living with chronic HCV. 4 Since 2011, many in the medical community saw glimpses of the elimination of HCV with the advent of new HCV direct acting antivirals (DAAs) with real-world efficacies above 95% of treated patients. 5 However, with ...

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  • Field Efficacy Study of Gamithromycin for the Control of ...

    2021-3-15 · had been treated with antimicrobials within 30 days prior to enrollment, or had transit time to the study site in excess of 24 hours were excluded. Processing Cattle at the Texas site were received on Day -1 and processed on Day 0. At processing, each animal received a uniquely numbered ear tag. A viral respiratory vaccine (Reli-

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  • Evaluation of the antibacterial activity of tilmicosin

    2018-8-17 · Evaluation of the antibacterial activity of tilmicosin-SLN against Streptococcus agalactiae: in vitro and in vivo studies Luyan Zhu,1 Xiaoxia Cao,1 Qinxin Xu,1 Jing Su,1 Xihe Li,2,3 Wenzhong Zhou1 1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People’s Republic of China; 2Research Center for Animal Genetic ...

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  • Impact of Nasal Saline Irrigations on Viral Load in ...

    2020-4-15 · Respiratory viral infection i.e., SARS-CoV-2 infection is expected to activate TLR2, TLR3, TLR4 and TLR7 responses and this is likely to modulate commensal microbiota populations. It is not yet known if the severity of SARS-CoV-2 disease in older adults is due to a biased host response, SARS-CoV-2 virulence determinants, or the impact infection ...

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  • siRNA Therapeutics against Respiratory Viral

    2021-1-27 · 1 Introduction. Acute viral respiratory tract infections (AVRIs) are a major burden on human health and global economy. Even before the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019, AVRIs were amongst the top five causes of death worldwide resulting in an estimated 3.9 million lives lost every year.

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  • ffects of Respiratory Disease Risk and a Bolus Injection ...

    2018-4-23 · cinated, treated for parasites, and weaned upon arrival at the feedlot. All steers were fed the same receiving diet ad libitum for a period of 28 d and moni-tored twice daily for symptoms of respira-tory disease. Respiratory disease risk level did not affect receiving ADG (P = 0.78); however, HI steers had greater (P < 0.01)

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  • Macrolide Therapy in Respiratory Viral Infections

    2012-6-6 · 4.1. Cell Culture Studies. Among in vitro, in vivo, and clinical studies, in vitro studies, especially cell culture studies, were most frequently performed to evaluate the effect of macrolides on respiratory viral infection. Numerous in vitro studies with various respiratory virus revealed that macrolides are effective on respiratory viral infections.. RV is the most common cause of viral ...

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  • American Journal of Respiratory and Critical Care

    2017-9-6 · 1 State Key Laboratory of Respiratory Disease, ... Neurons were treated with the contrast solution in the control group or IFN-γ (1 ng/ml) in the IFN-γ group. Neurons were stained with anti–phospho-Stat1 (green) and Hoechst 33342 (blue) and imaged by confocal microscopy. ... Effect of viral upper respiratory tract infection on the urge-to ...

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  • Could We Be Wrong About Ivermectin And COVID-19 ...

    2021-7-7 · An anti-viral will reduce viral shedding, taken as the measure of disease severity, only if given very early, within 12 hours of initial symptoms, with maybe an outer limit of 48 hours. While the analogy is not perfectly matched, it is the same time course we expect with Tami-Flu, given early is reduces the time course of the flu.

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  • Drug Discovery Strategies for SARS-CoV-2 | Journal of ...

    2021-3-20 · Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction and immune response dysregulation. Co-Q10 is an enzyme cofactor in mitochondria can control asthma and allergic rhinitis symptoms. In the present study, we determined that the CoQ10 ...

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  • Evaluation of the antibacterial activity of tilmicosin

    2018-8-17 · Evaluation of the antibacterial activity of tilmicosin-SLN against Streptococcus agalactiae: in vitro and in vivo studies Luyan Zhu,1 Xiaoxia Cao,1 Qinxin Xu,1 Jing Su,1 Xihe Li,2,3 Wenzhong Zhou1 1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People’s Republic of China; 2Research Center for Animal Genetic ...

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  • CAS 137330-13-3 Tilmicosin Phosphate - BOC Sciences

    Tilmicosin phosphate, an antibiotic, has been commonly used as a veterinary drug against ovine respiratory disease for bovine and ovine. Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

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  • siRNA Therapeutics against Respiratory Viral

    2021-1-27 · 1 Introduction. Acute viral respiratory tract infections (AVRIs) are a major burden on human health and global economy. Even before the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019, AVRIs were amongst the top five causes of death worldwide resulting in an estimated 3.9 million lives lost every year.

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  • JCI Insight - TLR2-mediated activation of innate

    2021-2-9 · 2 Viral Immunology and Respiratory Disease group, School of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia. 3 Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.

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  • Viruses | Free Full-Text | Brilacidin Demonstrates ...

    Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019. There is a critical global need for therapeutic intervention strategies that can be deployed to safely treat COVID-19 disease and reduce associated morbidity and mortality.

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  • Immuno-modulating properties of Tulathromycin in

    2019-8-23 · Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-stranded RNA virus that grows in macrophages and causes acute pneumonia in pigs. PRRSV causes devastating losses to the porcine industry. However, due to its high antigenic variability and poorly understood immunopathogenesis, there is currently no effective vaccine or treatment to control PRRSV infection.

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  • Coronavirus Disease 2019–COVID-19 | Clinical

    SARS is a viral respiratory disease caused by a formerly unrecognized animal CoV that originated from the wet markets in southern China after adapting to the human host, thereby enabling transmission between humans . The SARS outbreak reported in 2002 to 2003 had 8,098 confirmed cases with 774 total deaths (9.6%) .

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  • Advances in vaccine delivery systems against viral ...

    2021-3-10 · MERS-CoV, which was first identified in Saudi Arabia in 2012, is a viral respiratory disease caused by coronavirus . More than 2000 cases MERS-CoV infection, which has typical symptoms including fever, cough, and shortness of breath, have been reported by WHO since September 2012 in around 27 countries .

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  • Association between antimicrobial drug class for

    2019-12-13 · Although 90% of BRD relapses are reported to receive retreatment with a different class of antimicrobial, studies examining the impact of antimicrobial selection (i.e. bactericidal or bacteriostatic) on retreatment outcomes and the emergence of antimicrobial resistance (AMR) are deficient in the published literature. This survey was conducted to determine the association between antimicrobial ...

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  • Predicting bovine respiratory disease outcome in

    2020-11-28 · Abstract. Bovine respiratory disease (BRD) is the most significant disease affecting feedlot cattle. Indicators of BRD often used in feedlots such as visual signs, rectal temperature, computer-assisted lung auscultation (CALA) score, the number of BRD treatments, presence of viral pathogens, viral seroconversion, and lung damage at slaughter vary in their ability to predict an animal’s BRD ...

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  • Pharmacovigilance of Tilmicosin in Mice - UFRGS

    2015-11-7 · therapy for pneumonia and other respiratory disease conditions in cattle and sheep, formulated as 100 mL amber glass vials containing 333.828 mg tilmicosin phosphate/mL, equivalent to 300 mg tilmicosin/mL. The drug solution was further diluted in sterile water to adjust dose volumes as 0.3 mL diluted solution

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  • In Vitro Antiviral Activity and Projection of

    2020-3-9 · Xueting Yao, Fei Ye, Miao Zhang, Cheng Cui, Baoying Huang, Peihua Niu, Xu Liu, Li Zhao, Erdan Dong, Chunli Song, Siyan Zhan, Roujian Lu, Haiyan Li, Wenjie Tan, Dongyang Liu, In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clinical Infectious Diseases, …

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  • Study to Assess the Efficacy, Safety, and Tolerability

    2021-1-8 · The E-RS: COPD is administered as a part of the 14-item EXACT questionnaire and is completed on a daily basis.The 11-item E-RS:COPD assesses severity of respiratory symptoms overall and severity of individual symptoms such as breathlessness, cough and sputum, and chest symptoms The total score of E-RS:COPD ranges from 0 to 40, with higher ...

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  • Favipiravir antiviral efficacy against SARS-CoV-2 in a ...

    2021-3-19 · Viral RNA was quantified in lungs, large bowel, and plasma from sacrificed animals 2, 3, 4, and 7 dpi (Supplementary Fig. 2 and Supplementary Data 1). Viral loads in lungs peaked at 2 and 3 dpi with inocula of 10 5 and 10 4 TCID 50, respectively. Maximum viral loads in lungs of animals infected with each virus inoculum were comparable.

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  • Nebulised ALX-0171 for respiratory syncytial virus

    2020-9-28 · Because early treatment might limit clinical progression of viral disease better than later treatment, a post-hoc descriptive analysis on early treatment was done, subgrouping time between onset of RSV symptoms and start of dosing less than 3 days before symptom onset versus 3 days or more after symptom onset. 56 children in the ALX-0171 groups ...

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  • Coating with Hypertonic Saline Improves Virus Protection ...

    2021-7-11 · airborne viral particles. Incorrect donning and doffing of masks and a lack of hand-hygiene cause contagion by the wearers’ own hands. This study aimed to prove that hypertonic saline effectively reduces the infectious viral load on treated masks. Therefore, a hypertonic salt solution·s protective

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  • Investigating a safe ventilation rate for the prevention ...

    2017-8-25 · likely to be captured into the respiratory tract and produce infection (McCluskey et al. 1996). If particles carrying pathogens are inhaled by and deposited into the respiratory tract of a susceptible individual, disease can result. Thus, when dealing with airborne transmission, a primary concern

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  • Characterization of orally efficacious influenza drug

    2021-3-10 · MERS-CoV, which was first identified in Saudi Arabia in 2012, is a viral respiratory disease caused by coronavirus . More than 2000 cases MERS-CoV infection, which has typical symptoms including fever, cough, and shortness of breath, have been reported by WHO since September 2012 in around 27 countries .

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  • Annex 4 Guidelines on viral inactivation and removal ...

    Guidelines on viral inactivation and removal procedures intended to assure the viral safety of human blood plasma products List of abbreviations and definitions used in this Annex 151 1. Introduction and scope 154 2. General considerations 155 3. Infectious agents 157 3.1 Viruses, viral burden and screening methods 157 3.2 Other infectious ...

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  • Prevention and Treatment of Viral Infections | Biology II

    A virus is a small parasite that cannot reproduce by itself. Once it infects a susceptible cell, however, a virus can direct the cell machinery to produce more viruses. Most viruses have either RNA or DNA as their genetic material. The nucleic acid may be single- or double-stranded. The entire infectious virus particle, called a virion, consists of the nucleic acid and an outer shell of protein.

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  • Viruses: Structure, Function, and Uses - Molecular Cell ...

    2011-7-31 · In this session we will take an evidence-based medicine approach to ancillary therapy of bovine respiratory disease, bovine toxic mastitis, bovine neonatal enteric disease, and retained placenta/metritis. The literature reviewed here is not presented as being all-inclusive, but rather as a summary of many commonly cited articles on these subjects.

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  • Beyond the antimicrobial: what's the evidence for

    Fax +39 0223 511894. Email [email protected] Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing global pandemic known as COVID-19. Based on the potential antiviral role of quercetin, and on its described anti-blood clotting, anti-inflammatory and antioxidant properties, we ...

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  • Potential clinical benefits of quercetin in COVID-19 |

    2021-5-28 · Design: A case-control study investigating the association of a nasopharyngeal wash and viral load in adult patients who tested positive for COVID-19 and were hospitalized was performed. All patients were treated with the standard protocol of care for COVID-19.

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  • Nemertes:First report of reduced severe acute

    2021-1-5 · Coronavirus disease 2019 (COVID-19), a pneumonia-like disease caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reached pandemic proportions in early 2020. 1, 2 A subset of subjects infected by SARS-CoV-2 develop severe COVID-19 requiring hospitalization. 3, 4 Severe COVID-19 is believed to result from ...

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  • Umbilical cord mesenchymal stem cells for COVID‐19

    2021-2-26 · The mechanism for spread of SARS-CoV-2 has been attributed to large particles produced by coughing and sneezing. There is controversy whether smaller airborne particles may transport SARS-CoV-2. Smaller particles, particularly fine particulate matter (≤ 2.5 µm in diameter), can remain airborne for longer periods than larger particles and after inhalation will penetrate deeply into the lungs.

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  • Characterization of hospital ... - Respiratory Research

    2021-7-16 · At the appearance of disease: 1. Treat the tank with a disinfectant and clean the tank as best as possible. 2. To disinfect, use acriflavine (trypaflavine) or monacrin (mono-amino-acridine) using a 0.2% solution at the rate of 1 ml per litre. Both disinfectants will colour the water, but the colour disappears as the disinfectants dissipate. 3.

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  • Modulating Effects of Spirulina platensis against ...

    2018-5-19 · Objective: Tilmicosin (TIL) is a long-acting macrolide antibiotic used to treat cattle for pathogens that cause bovine respiratory disease. However, overdoses of this medication have been reported to induce cardiac damage. Our experimental objective was to evalu-ate the protective effects of Spirulina platensis (SP) administration against TIL ...

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  • siRNA Therapeutics against Respiratory Viral

    2021-1-27 · 1 Introduction. Acute viral respiratory tract infections (AVRIs) are a major burden on human health and global economy. Even before the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019, AVRIs were amongst the top five causes of death worldwide resulting in an estimated 3.9 million lives lost every year.

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  • Annex 4 of the Prevention and Control Plan Coronavirus ...

    2020-3-8 · Translated by Chinese Center for Disease Control and Prevention Annex 4 of the Prevention and Control Plan Coronavirus Disease 2019 (Fifth Edition) COVID-19: Laboratory Testing Guideline This technical guideline is formulated to guide disease control agencies and relevant institutions at all levels to carry out laboratory testing for COVID-19.

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  • Viruses | Free Full-Text | Brilacidin Demonstrates ...

    Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019. There is a critical global need for therapeutic intervention strategies that can be deployed to safely treat COVID-19 disease and reduce associated morbidity and mortality.

    Get Price
  • Clinical benefit of remdesivir in rhesus macaques infected ...

    2020-4-15 · respiratory tract disease. Two groups of six rhesus macaques were infected with SARS-CoV-2 and treated with intravenous remdesivir or an equal volume of vehicle solution once daily. Clinical, virological and histological parameters were assessed regularly during the study and at necropsy to determine treatment efficacy. Results:

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  • The potential of herbal extracts to inhibit SARS-CoV-2:

    2021-3-8 · Herbal medicinal products have a long-standing history of use in the therapy of common respiratory infections. We sought to assess the potential of five validated herbal extracts regarding their ability to restrict SARS-CoV-2 replication in vitro: Bronchipret thyme-ivy (BRO TI), Bronchipret thyme-primrose (BRO TP), Imupret (IMU), Sinupret extract (SINx) and Tonsipret (TOP).

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  • Coronavirus Disease 2019–COVID-19 | Clinical

    SARS is a viral respiratory disease caused by a formerly unrecognized animal CoV that originated from the wet markets in southern China after adapting to the human host, thereby enabling transmission between humans . The SARS outbreak reported in 2002 to 2003 had 8,098 confirmed cases with 774 total deaths (9.6%) .

    Get Price
  • DP1 prostanoid receptor activation increases the

    2021-4-20 · Viral bronchiolitis is one of the major causes of hospitalization and premature death in children under 5 years of age. 1 An infection with respiratory syncytial virus (RSV) is the most common ...

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  • Antibody-Dependent Enhancement of Virus Infection

    2004-7-9 · This activity is known as antibody-dependent enhancement (ADE) of virus infection. The ADE of virus infection is a phenomenon in which virus-specific antibodies enhance the entry of virus, and in some cases the replication of virus, into monocytes/macrophages and granulocytic cells through interaction with Fc and/or complement receptors.

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  • Predicting bovine respiratory disease outcome in

    2020-12-1 · Bovine respiratory disease (BRD) is the most significant disease affecting feedlot cattle. Indicators of BRD often used in feedlots such as visual signs, rectal temperature, computer-assisted lung auscultation (CALA) score, the number of BRD treatments, presence of viral pathogens, viral seroconversion, and lung damage at slaughter vary in their ability to predict an animal’s BRD outcome ...

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  • O’Sullivan TL, Johnson R, Poljak Z, et al. An

    The reason tilmicosin is commonly chosen as a medication during a PRRSV outbreak is that tilmicosin is considered an effective antibiotic for many swine respiratory bacterial pathogens and also because there are reports of tilmicosin having some antiviral efficacy, at least in vitro. 10 Tilmicosin, a semi-synthetic macrolide antibiotic, is ...

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  • Use of Silver in the Prevention and Treatment of ...

    2021-7-17 · Results. Since Fox's work, the use of topical silver to reduce bacterial burden and promote healing has been investigated in the setting of chronic wounds and ulcers, post-operative incision dressings, blood and urinary catheter designs, endotracheal tubes, orthopedic devices, vascular prostheses, and the sewing ring of prosthetic heart valves.

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  • Pharmacokinetics and Pulmonary Disposition of ...

    2020-7-9 · demonstrated the efficacy of tilmicosin in the treatment of respiratory disease in these species (Musser et al., 1996; Paradis et al., 2004). Lung concentrations of tilmicosin remain above the MIC ofMannheimia haemolytica (3.15 [tg/mL) for at least 72 hours following a single SC injection at a dose of 10 mg/kg (Micotil 300 package insert, 1995).

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  • Modulating Effects of Spirulina platensis against ...

    2018-5-19 · Objective: Tilmicosin (TIL) is a long-acting macrolide antibiotic used to treat cattle for pathogens that cause bovine respiratory disease. However, overdoses of this medication have been reported to induce cardiac damage. Our experimental objective was to evalu-ate the protective effects of Spirulina platensis (SP) administration against TIL ...

    Get Price
  • Update in Asthma 2014 | American Journal of

    2015-3-25 · These insights implicate the bacterial microbiome and environmental product exposure as early determinants of respiratory disease . Rhinovirus (RV) is a well-known cause of asthma exacerbations, despite a seemingly paradoxical relationship between type 1 inflammation induced by viral illness and type 2 inflammation of an asthma exacerbation.

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  • Antibody-Dependent Enhancement of Virus Infection

    2004-7-9 · This activity is known as antibody-dependent enhancement (ADE) of virus infection. The ADE of virus infection is a phenomenon in which virus-specific antibodies enhance the entry of virus, and in some cases the replication of virus, into monocytes/macrophages and granulocytic cells through interaction with Fc and/or complement receptors.

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  • Insights of Severe Acute Respiratory Syndrome

    2021-2-1 · COVID-19, a pandemic of the 21st century caused by novel coronavirus SARS-CoV-2 was originated from China and shallowed world economy and human resource. The medical cures via herbal treatments, antiviral drugs, and vaccines still in progress, and studying rigorously. SARS-CoV-2 is more virulent than its ancestors due to evolution in the spike protein(s), mediates viral attachment to the …

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  • A descriptive study of acute outbreaks of respiratory ...

    2020-6-24 · Respiratory diseases are major health concerns in the pig production sector worldwide, contributing adversely to morbidity and mortality. Over the past years there was a rise in reported incidents of respiratory disease in pigs in Norway, despite population wide freedom from Aujeszky´s disease, porcine reproductive and respiratory syndrome, porcine respiratory corona virus and enzootic …

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  • Design of dosage forms | Clinical Gate

    2015-2-8 · Dosage forms can be designed for administration by alternative delivery routes to maximize therapeutic response. Preparations can be taken orally or injected, as well as being applied to the skin or inhaled, and Table 1.1 lists the range of dosage forms which can be used to deliver drugs by the various administration routes.

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  • Nemertes:First report of reduced severe acute

    2021-5-28 · Design: A case-control study investigating the association of a nasopharyngeal wash and viral load in adult patients who tested positive for COVID-19 and were hospitalized was performed. All patients were treated with the standard protocol of care for COVID-19.

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  • Testing of the inhibitory effects of loratadine and ...

    2021-4-1 · Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by a newly discovered, highly pathogenic coronavirus, namely severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [1, 2]. Since the outbreak of the disease in December 2019, this coronavirus has rapidly spread to many countries worldwide.

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  • Pharmacokinetic and pharmacodynamic properties of ...

    2021-4-16 · respiratory disease on tilmicosin pharmacokinetics. It was found that tilmicosin ... Among other species in which tilmicosin was investigated, rabbits treated with a subcutaneous dose of 25 mg/kg tilmicosin had a Cma, of 1.91 pg/ml and tm~, of 2 hours ... MICOTIL 300 is a 30% solution of tilmicosin in propylene glycol, and the label

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  • Pharmacokinetics and Pulmonary Disposition of ...

    2020-7-9 · demonstrated the efficacy of tilmicosin in the treatment of respiratory disease in these species (Musser et al., 1996; Paradis et al., 2004). Lung concentrations of tilmicosin remain above the MIC ofMannheimia haemolytica (3.15 [tg/mL) for at least 72 hours following a single SC injection at a dose of 10 mg/kg (Micotil 300 package insert, 1995).

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  • Treatment and vaccines for severe acute respiratory ...

    The causative agent of severe acute respiratory syndrome (SARS), which affected over 8000 individuals worldwide and was responsible for over 700 deaths in the 2002–2003 outbreak, is a coronavirus that was unknown before the outbreak. Although many different treatments were used during the outbreak, none were implemented in a controlled fashion. Thus, the optimal treatment for SARS is unknown ...

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  • The SARS-CoV-2 viral load in COVID-19 patients is

    2021-6-29 · Maltezou, H. C. et al. Association between upper respiratory tract viral load, comorbidities, disease severity and outcome of patients with SARS-CoV-2 infection. J. Infect.

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    2017-8-25 · likely to be captured into the respiratory tract and produce infection (McCluskey et al. 1996). If particles carrying pathogens are inhaled by and deposited into the respiratory tract of a susceptible individual, disease can result. Thus, when dealing with airborne transmission, a primary concern

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    The nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus plays important roles in both viral replication and modulation of host cell processes. New ligands that target the N protein may thus provide tools to track the protein inside cells, detect interaction hot spots on the protein surface, and discover sites that could be used to develop new anti-SARS therapies.

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  • Update in Asthma 2014 | American Journal of

    2015-3-25 · These insights implicate the bacterial microbiome and environmental product exposure as early determinants of respiratory disease . Rhinovirus (RV) is a well-known cause of asthma exacerbations, despite a seemingly paradoxical relationship between type 1 inflammation induced by viral illness and type 2 inflammation of an asthma exacerbation.

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    2020-6-24 · Respiratory diseases are major health concerns in the pig production sector worldwide, contributing adversely to morbidity and mortality. Over the past years there was a rise in reported incidents of respiratory disease in pigs in Norway, despite population wide freedom from Aujeszky´s disease, porcine reproductive and respiratory syndrome, porcine respiratory corona virus and enzootic …

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  • Diagnosis of Bovine Respiratory Disease in feedlot

    2020-1-10 · Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil. Journal of Infection in Developing Countries 11 , 791–799, https://doi.org ...

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