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  • Preparation, characterization and pharmacokinetics of ...

    2016-5-1 · Doxycycline hydrochloride (DoxHcl) and florfenicol (FF) are intensively used to control the porcine respiratory disease due to their excellent antibacterial activities , but their clinical efficacy is always unsatisfactory because of their physicochemical and pharmacokinetic shortcoming and the infection complexity as well as severity of pig pneumonia.

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    2004-5-10 · ministration of oxytetracycline hydrochloride in water at a dosage of 20 to 40 mg/kg (9 to 18 mg/lb), every 12 hours, for 3 to + days in adult animals. In preruminant calves, a meat withdrawal time of 21 days after admin-istration at the rate of 30 mg/kg/d (13.5 mg/ibld) for 4 days should be appropriate.

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    Doxycycline Hyclate is the hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis.

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    2017-7-18 · FOR SWINE, CALVES AND TURKEYS: 2.52 oz. (two scoops) dissolved in 500 mL (approximately 17 fl. oz.) of warm water will provide a stock solution of 100 mg of tetracycline hydrochloride activity per mL. FOR TURKEYS ONLY: This stock solution when metered at approximately 1 oz. per gallon, will provide drinking water containing 2,957 mg of ...

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    Doxycycline diffuses readily into most body tissues, fluid and/or cavities and the volume of distribution has been measured as 0.7 L/kg 14. Protein binding >90% Label, 15. Metabolism. Doxycycline is metabolized in the liver and gastrointestinal tract and concentrated in bile Label, 15.

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    The invention relates to a long-acting veterinary compound doxycycline injection, which consists of doxycycline or doxycycline hydrochloride serving as a main medicament, a synergist, a solvent, a complexing agent, an antioxidant and a pH regulator, wherein the main medicament adopts the doxycycline or the doxycycline hydrochloride, and the doxycycline content is 10.0 to 20.0 grams; the …

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    2004-5-10 · of a long-acting preparation .of oxytetracycline at 20 mg/kg. A milk withdrawal interval of 192 hours could be conservatively extrapolated for use of oxytetracy-cline at 20 to 30 mg/kg (9.0 to 13.5 mg/ib). A minimum meat withdrawal time of 35 days should be observed when short-acting …

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    Acknowledgements: The EMA CVMP and the EFSA BIOHAZ Panel wish to thank the following for the support provided to this scientific opinion: the EFSA Panel on Animal Health and Welfare (AHAW), which endorsed Section 4.2 of the scientific opinion; the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), which endorsed Section 4.4 of the scientific opinion; the EMA ...

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    Slaughter of animals and poultry for meat is allowed 10 (calves, lambs, swine, rabbits) and 7 (poultry) days after the last application of the drug. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

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    2015-5-1 · Respiratory infections represent a major global health problem. They are often treated by parenteral administrations of antimicrobials. Unfortunately, systemic therapies of high-dose antimicrobials can lead to severe adverse effects and this calls for a need to develop inhaled formulations that enable targeted drug delivery to the airways with minimal systemic drug exposure.

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    Slaughter of animals and poultry for meat is allowed 11 days (calves, lambs, goats), 8 days (swine) and 3 days (broiler chickens) after the last drug application. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

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  • Tetracyclines - Pharmacology - Merck Veterinary Manual

    All of the tetracycline derivatives are crystalline, yellowish, amphoteric substances that, in aqueous solution, form salts with both acids and bases. They characteristically fluoresce when exposed to ultraviolet light. The most common salt form is the hydrochloride, except for doxycycline, which is available as doxycycline hyclate or monohydrate. The tetracyclines are stable as dry powders ...

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  • The Wound Healing Effect of Doxycycline after

    2019-10-10 · Purpose . To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods . Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the doxycycline group and the control group, with 84 rats in each group. 1.0 g·L −1 doxycycline eye drops (doxycycline group) or vehicle ...

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  • Poultry Products - FARAD's Species Pages

    2020-2-6 · A water soluble powder containing 324 grams tetracycline hydrochloride activity per pound. For prevention and treatment of diseases susceptible to tetracycline in calves, swine, and poultry. • Extremely good solubility. • Specifically developed for medicating poultry and livestock through automatic watering systems.

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  • Biotransformation of doxycycline by Brevundimonas ...

    2021-6-5 · 1. Introduction. Doxycycline (DC) is a second generation tetracycline antibiotic synthesized by deoxygenating the C6 position of oxytetracycline (Nogueira et al., 2011, Das et al., 2019).Compared to the first generation tetracycline antibiotics, DC (C 22 H 24 N 2 O 8, 444.44 g mol −1 (Borghi et al., 2015, Fan et al., 2019)) is a safer alternative (Heaton et al., 2007), because it is more ...

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    2021-4-13 · Long-acting, selective beta 2-agonists (LABAs) are FDA-approved for use as adjunctive therapy with long-term asthma control medications, such as inhaled corticosteroids (ICS), in managing reversible obstructive airways disease, including asthma and nocturnal asthma, in patients inadequately controlled with long-term asthma control medications.

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    Slaughter of animals and poultry for meat is allowed 11 days (calves, lambs, goats), 8 days (swine) and 3 days (broiler chickens) after the last drug application. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

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    2004-5-10 · of a long-acting preparation .of oxytetracycline at 20 mg/kg. A milk withdrawal interval of 192 hours could be conservatively extrapolated for use of oxytetracy-cline at 20 to 30 mg/kg (9.0 to 13.5 mg/ib). A minimum meat withdrawal time of 35 days should be observed when short-acting …

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  • The Wound Healing Effect of Doxycycline after

    2019-10-10 · Purpose . To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods . Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the doxycycline group and the control group, with 84 rats in each group. 1.0 g·L −1 doxycycline eye drops (doxycycline group) or vehicle ...

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    2/27 REV. 1 AGREED BY THE EFFICACY WORKING PARTY January 2010 REV. 1 ADOPTION BY CHMP 20 January 2010 REV. 1 DATE FOR COMING INTO EFFECT 1 August 2010 This guideline will replace the “Note for guidance on the investigation of bioavailability and

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  • Biotransformation of doxycycline by Brevundimonas ...

    2021-6-5 · 1. Introduction. Doxycycline (DC) is a second generation tetracycline antibiotic synthesized by deoxygenating the C6 position of oxytetracycline (Nogueira et al., 2011, Das et al., 2019).Compared to the first generation tetracycline antibiotics, DC (C 22 H 24 N 2 O 8, 444.44 g mol −1 (Borghi et al., 2015, Fan et al., 2019)) is a safer alternative (Heaton et al., 2007), because it is more ...

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  • TRIMECOL | Biopharm - development, production

    Slaughter of animals and poultry for meat is allowed 10 (calves, lambs, swine, rabbits) and 7 (poultry) days after the last application of the drug. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

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  • Rapid detection of ractopamine and salbutamol in

    Introduction. Ractopamine (RAC) and salbutamol (SAL) are β-agonists, as are several drugs collectively called “clenbuterol”. 1 RAC and SAL were originally used to treat bronchitis and asthma. In recent years, they have been illegally used to increase the feed conversion rate in animal husbandry because the large-scale use of β-agonists can promote animal body fat decomposition and ...

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  • Safety and efficacy of COXAM® (amprolium

    2018-7-11 · The coccidiostat amprolium hydrochloride from COXAM® is considered safe for chickens for fattening at 125 mg/kg complete feed. The margin of safety is at least 5. This conclusion is extended to chickens reared for laying. Amprolium hydrochloride does not possess any significant antibacterial activity. The applicant provided no information on the absorption, distribution, metabolism and ...

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  • ICH guideline practice: application of validated RP

    2013-7-18 · Tapentadol is a novel centrally acting analgesic. There is no method for the determination of drug content in dosage form without any interference of any excipients and without using the diethylamine content in the mobile phase with UV detection. A simple, precise, and accurate new reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated as per ...

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  • Amino Acid Concentrate for cattle, swine, sheep

    Store in a cool dry place. Overview. Cattle receive 1 oz. per 100 lbs. of body weight. Put 10 oz. in the drinking water per day for a 1,000 lb. horse. Sheep and swine receive 1/2 oz. per 50 lbs. in their drinking water to be consumed in one day. Main Ingredients. Propylene glycol. Sorbitol.

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  • Oxytet Soluble Antibiotic Powder

    LinxMed-SP Soluble Powder is used for the treatment of dysentery in swine (bloody scours) and for the control of necrotic enteritis in broiler chickens. LinxMix SP contains lincomycin hydrochloride. For swine treatment, 1 packet will medicate 128 gallons drinking water; administer for a …

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  • Pennox 343 Oxytetracycline Hydrochloride Soluble

    2013-3-26 · General: Diphenhydramine hydrochloride has an atropine-like action and, therefore should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroid-ism, cardiovascular disease or hypertension. Use with caution in patients with lower respiratory disease including asthma.

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    2/27 REV. 1 AGREED BY THE EFFICACY WORKING PARTY January 2010 REV. 1 ADOPTION BY CHMP 20 January 2010 REV. 1 DATE FOR COMING INTO EFFECT 1 August 2010 This guideline will replace the “Note for guidance on the investigation of bioavailability and

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  • Diphenhydramine Hydrochloride Injection

    Acknowledgements: The EMA CVMP and the EFSA BIOHAZ Panel wish to thank the following for the support provided to this scientific opinion: the EFSA Panel on Animal Health and Welfare (AHAW), which endorsed Section 4.2 of the scientific opinion; the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), which endorsed Section 4.4 of the scientific opinion; the EMA ...

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  • Guideline o the Investigation of Bioequivalence

    FUBACIN 5% powder is indicated for the control and treatment of the following parasites: Swine : Ascaris suum, Hyostrongylus rubidus, Oesophagostomum dentatum, Trichuris suis, Strongyloides ransomi, Metastrongylus apri Poultry (Chicken, turkey, pheasant) Syngamus trachea, Ascaridia galli, Heterakis, gallinarum, Capillaria spp., Amidostomum ...

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  • EMA and EFSA Joint Scientific Opinion on measures to ...

    2021-4-13 · Long-acting, selective beta 2-agonists (LABAs) are FDA-approved for use as adjunctive therapy with long-term asthma control medications, such as inhaled corticosteroids (ICS), in managing reversible obstructive airways disease, including asthma and nocturnal asthma, in patients inadequately controlled with long-term asthma control medications.

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  • Swine (Pig) Veterinary Medicine Supplies &

    2009-1-1 · SM forms sulfonium ion in the body and alkylates DNA leading to DNA strand breaks and cell death. Due to the high electrophilic property of the sulfonium ion, SM binds to a variety of cellular macromolecules (Dacre and Goldman, 1996, Somani and Babu, 1989).The most common complications of SM occur in lung, skin, and eye which are the principal target organs due to its direct effect.

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    2021-6-1 · Quality First,and Customer Supreme is our guideline to provide the best service to our customers.Nowadays, we are trying our best to become one of the best exporters in our field to meet customers more need for Doxycycline Hydrochloride Injection 10%, Functions Of Iron Dextran Injection, Tetramiosole Hydrochloride Soluble Powder, Tylosin Tartrate Injection Formulation, We sincerely …

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    SUPPLEMENTAL NEW ANIMAL DRUG APPLICATION . NADA 141-288 EXCENEL ® RTU EZ ceftiofur hydrochloride. Injectable Suspension. Swine. This supplement provides for . an increase in the maximum injection site volume in swine from 5 mL to 15 mL. The larger maximum injection site volume will reduce the number of injections needed in larger pigs ...

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  • Tetroxy HCA-1400 Soluble Powder (Bimeda) | QC Supply

    This 3.09 lb packet of Tetroxy HCA-1400 soluble powder is used for the treatment and control of specific diseases in swine, turkey and chickens. This 1,400 g pouch of Tetroxy® HCA-1400 Soluble Powder from Bimeda® is for use in the drinking water of poultry and swine as a control of specific diseases susceptible to oxytetracycline.

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    FUBACIN 5% powder is indicated for the control and treatment of the following parasites: Swine : Ascaris suum, Hyostrongylus rubidus, Oesophagostomum dentatum, Trichuris suis, Strongyloides ransomi, Metastrongylus apri Poultry (Chicken, turkey, pheasant) Syngamus trachea, Ascaridia galli, Heterakis, gallinarum, Capillaria spp., Amidostomum ...

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    hydrochloride sterile suspension (EXCENEL RTU Sterile Suspension) or ceftiofur sodium sterile solution (NAXCEL Sterile Powder) was demonstrated after intramuscular or subcuta­ neous administration of ceftiofur hydrochloride and intramuscular administration of ceftiofur sodium at 1.0 mg ceftiofur equivalents/lb (2.2 mg/kg) BW.

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    ESMOLOL HYDROCHLORIDE 2500 mg powder is indicated for supraventricular tachycardia (except for pre- excitation syndromes), and for the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other circumstances where short-term control of the ventricular rate with a short acting agent is desirable.

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    Dry powder inhaler (DPI), breath-activated device (Turbuhaler®) Salmeterol (long-acting) 25 – 50 micrograms (1 to 2 puffs of 25 micrograms) Twice daily. 50 micrograms, twice daily. DPI, breath-activated device with each dose contained in a disc of eight doses (Accuhaler®) and standard MDI. Indacterol * (long-acting) 150 – 300 micrograms

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    Memantine hydrochloride . Memantine chemical name (IUPAC) is 3,5-dimethyladamantan-1-amine hydrochloride . It appears as is a white, almost odourless crystalline powder, highly soluble in water. Its pKa-value is 10.3 and shows a partition coefficient of log P = 3.28The active substance has two chiral centres but since there is a .

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    2002-6-1 · Significant FDA Approvals in 2001. THOMAS J. MCGINNIS, R.PH., Director of Pharmacy Affairs, U.S. Food and Drug Administration, Rockville, Maryland. Am Fam Physician. 2002 Jun 1;65 (11):2377-2383 ...

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    Generic Name Magnesium sulfate DrugBank Accession Number DB00653 Background. A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia.

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  • Drug Use Criteria: Aerosolized Agents - Metered-Dose ...

    2021-4-13 · Long-acting, selective beta 2-agonists (LABAs) are FDA-approved for use as adjunctive therapy with long-term asthma control medications, such as inhaled corticosteroids (ICS), in managing reversible obstructive airways disease, including asthma and nocturnal asthma, in patients inadequately controlled with long-term asthma control medications.

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  • ICH guideline practice: application of validated RP

    2013-7-18 · Tapentadol is a novel centrally acting analgesic. There is no method for the determination of drug content in dosage form without any interference of any excipients and without using the diethylamine content in the mobile phase with UV detection. A simple, precise, and accurate new reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated as per ...

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    Method. A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm.

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    The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications.

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    2020-3-30 · The ‘intermediate-acting’ tetracyclines, demeclocycline and methacycline, have reported half-lives of about 12 and 14 hours respectively, although various sources cite values of 7 to 17 hours, and the ‘long-acting’ minocycline and doxycycline have half-lives of about 16 and 18 hours, with reported values anywhere between 11 to 26 and 12 ...

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  • Significant FDA Approvals in 2001 - Practice

    2002-6-1 · Significant FDA Approvals in 2001. THOMAS J. MCGINNIS, R.PH., Director of Pharmacy Affairs, U.S. Food and Drug Administration, Rockville, Maryland. Am Fam Physician. 2002 Jun 1;65 (11):2377-2383 ...

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    2021-6-22 · Lidocaine Hydrochloride Topical Jelly, 2% (ANDA 040433) - designate as RS FDA-2020-P-2017 Alston & Bird LLP Nicardipine Hydrochloride Premixed Injection, 0.1 mg/mL and 0.2 mg/mL, in 0.9% Sodium Chloride (NDA 022276) - designate as alt. RLD FDA …

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  • Long-Acting Fixed-Dose Combination Products for

    2020-4-29 · Long-Acting Fixed-Dose Combination Products ... 250 mcg/50 mcg inhalation powder 500 mcg/50 mcg inhalation powder Section I and/or II . ... Tiotropium bromide + olodaterol hydrochloride (such as Inspiolto Respimat) Umeclidinium bromide + vilanterol trifenatate (such as Anoro Ellipta) ...

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  • COVID-19, cytokines, inflammation, and spices: How

    Method. A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm.

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    2020-9-3 · Coronavirus disease 2019 (COVID-19) pandemic is spreading rapidly around the globe. By the establishment of an integrative system combining both traditional Chinese medicine (TCM) and western medicine, China has achieved good clinical efficacy in the prevention and control of the pandemic. The advantages of TCM in the treatment of COVID-19 include effective relief of symptoms, retarding the ...

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    Mycoplasma Pneumonia (Mycoplasma hyopneumoniae) in swine is a prevalent and costly disease that is a common and widely distributed throughout the year in all herds around the country.. Mycoplasma is defined as a chronic, clinically mild, infectious pneumonia of pigs characterized by its ability to produce a persistent dry cough, stunted growth, sporadic “flare-ups” of respiratory issues ...

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  • New erectile dysfunction drug in the pipeline -

    2021-2-17 · Tardyl (Promethazine Hydrochloride) with Codeine Syrup, a clear purple syrup with odor of grape menthol, contains Tardyl (Promethazine Hydrochloride) hydrochloride 6.25 mg/5 mL, codeine phosphate 10 mg/5 mL and alcohol 7 percent, and is available in 4 fluid ounce (118 mL), 8 fluid ounce (237 mL) and pint (473 mL).

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